Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses

ABSTRACT Extracellular vesicles (EVs) are major vehicles for transporting viruses en bloc among hosts. While RNA viruses make up the great majority of transmission by EVs, in a recent article in mBio (mBio 10:e00379-19, 2019, https://mbio.asm.org/content/10/2/e00379-19.long), Morris-Love and colleag...

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Autores principales:	Marianita Santiana, Nihal Altan-Bonnet
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	demyelinating disease exosome extracellular vesicle glia polyomavirus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7d35678451fe4be3854959d13a047afe
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spelling	oai:doaj.org-article:7d35678451fe4be3854959d13a047afe2021-11-15T15:55:25ZInsane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses10.1128/mBio.01024-192150-7511https://doaj.org/article/7d35678451fe4be3854959d13a047afe2019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01024-19https://doaj.org/toc/2150-7511ABSTRACT Extracellular vesicles (EVs) are major vehicles for transporting viruses en bloc among hosts. While RNA viruses make up the great majority of transmission by EVs, in a recent article in mBio (mBio 10:e00379-19, 2019, https://mbio.asm.org/content/10/2/e00379-19.long), Morris-Love and colleagues revealed that a double-stranded DNA (dsDNA) virus, JC polyomavirus (JCPyV), a major cause of progressive multifocal leukoencephalopathy (PML), can be released from and transmitted to other glia in EVs. This mode of transmission appears to be highly infectious, independent of the free virus attachment and entry receptors LSTc and 5-HT2, and protected from neutralizing antibodies. This novel form of JCPyV transmission may potentially explain its dissemination into the central nervous system (CNS) and its increased virulence.Marianita SantianaNihal Altan-BonnetAmerican Society for Microbiologyarticledemyelinating diseaseexosomeextracellular vesiclegliapolyomavirusMicrobiologyQR1-502ENmBio, Vol 10, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	demyelinating disease exosome extracellular vesicle glia polyomavirus Microbiology QR1-502
spellingShingle	demyelinating disease exosome extracellular vesicle glia polyomavirus Microbiology QR1-502 Marianita Santiana Nihal Altan-Bonnet Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses
description	ABSTRACT Extracellular vesicles (EVs) are major vehicles for transporting viruses en bloc among hosts. While RNA viruses make up the great majority of transmission by EVs, in a recent article in mBio (mBio 10:e00379-19, 2019, https://mbio.asm.org/content/10/2/e00379-19.long), Morris-Love and colleagues revealed that a double-stranded DNA (dsDNA) virus, JC polyomavirus (JCPyV), a major cause of progressive multifocal leukoencephalopathy (PML), can be released from and transmitted to other glia in EVs. This mode of transmission appears to be highly infectious, independent of the free virus attachment and entry receptors LSTc and 5-HT2, and protected from neutralizing antibodies. This novel form of JCPyV transmission may potentially explain its dissemination into the central nervous system (CNS) and its increased virulence.
format	article
author	Marianita Santiana Nihal Altan-Bonnet
author_facet	Marianita Santiana Nihal Altan-Bonnet
author_sort	Marianita Santiana
title	Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses
title_short	Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses
title_full	Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses
title_fullStr	Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses
title_full_unstemmed	Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses
title_sort	insane in the membrane: glial extracellular vesicles transmit polyomaviruses
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/7d35678451fe4be3854959d13a047afe
work_keys_str_mv	AT marianitasantiana insaneinthemembraneglialextracellularvesiclestransmitpolyomaviruses AT nihalaltanbonnet insaneinthemembraneglialextracellularvesiclestransmitpolyomaviruses
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Insane in the Membrane: Glial Extracellular Vesicles Transmit Polyomaviruses

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