Recent Advances in Pharmaceutical Cocrystals: From Bench to Market

The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stabi...

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Auteurs principaux:	Ravi Kumar Bandaru, Smruti Rekha Rout, Gowtham Kenguva, Bapi Gorain, Nabil A. Alhakamy, Prashant Kesharwani, Rambabu Dandela
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	solid dosage forms pharmaceutical cocrystals solubility permeability cocrystallization formulation Therapeutics. Pharmacology RM1-950
Accès en ligne:	https://doaj.org/article/7d35712f470145e8b50ff89ea57c7fc8
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spelling	oai:doaj.org-article:7d35712f470145e8b50ff89ea57c7fc82021-11-11T08:47:40ZRecent Advances in Pharmaceutical Cocrystals: From Bench to Market1663-981210.3389/fphar.2021.780582https://doaj.org/article/7d35712f470145e8b50ff89ea57c7fc82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.780582/fullhttps://doaj.org/toc/1663-9812The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stability, porosity, thermal properties, etc. The formation of salts, solvates, and polymorphs are the conventional strategies for altering the solid characteristics of pharmaceutical compounds, but they have their own limitations. Cocrystallization approach was established as an alternative method for tuning the solubility, permeability, and processability of APIs by introducing another compatible molecule/s into the crystal structure without affecting its therapeutic efficacy to successfully develop the formulation with the desired pharmacokinetic profile. In the present review, we have grossly focused on cocrystallization, particularly at different stages of development, from design to production. Furthermore, we have also discussed regulatory guidelines for pharmaceutical industries and challenges associated with the design, development and production of pharmaceutical cocrystals with commercially available cocrystal-based products.Ravi Kumar BandaruSmruti Rekha RoutGowtham KenguvaBapi GorainNabil A. AlhakamyNabil A. AlhakamyPrashant KesharwaniRambabu DandelaFrontiers Media S.A.articlesolid dosage formspharmaceutical cocrystalssolubilitypermeabilitycocrystallizationformulationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	solid dosage forms pharmaceutical cocrystals solubility permeability cocrystallization formulation Therapeutics. Pharmacology RM1-950
spellingShingle	solid dosage forms pharmaceutical cocrystals solubility permeability cocrystallization formulation Therapeutics. Pharmacology RM1-950 Ravi Kumar Bandaru Smruti Rekha Rout Gowtham Kenguva Bapi Gorain Nabil A. Alhakamy Nabil A. Alhakamy Prashant Kesharwani Rambabu Dandela Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
description	The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the chemicals to understand the physicochemical properties by particle size, size distribution, surface area, solubility, stability, porosity, thermal properties, etc. The formation of salts, solvates, and polymorphs are the conventional strategies for altering the solid characteristics of pharmaceutical compounds, but they have their own limitations. Cocrystallization approach was established as an alternative method for tuning the solubility, permeability, and processability of APIs by introducing another compatible molecule/s into the crystal structure without affecting its therapeutic efficacy to successfully develop the formulation with the desired pharmacokinetic profile. In the present review, we have grossly focused on cocrystallization, particularly at different stages of development, from design to production. Furthermore, we have also discussed regulatory guidelines for pharmaceutical industries and challenges associated with the design, development and production of pharmaceutical cocrystals with commercially available cocrystal-based products.
format	article
author	Ravi Kumar Bandaru Smruti Rekha Rout Gowtham Kenguva Bapi Gorain Nabil A. Alhakamy Nabil A. Alhakamy Prashant Kesharwani Rambabu Dandela
author_facet	Ravi Kumar Bandaru Smruti Rekha Rout Gowtham Kenguva Bapi Gorain Nabil A. Alhakamy Nabil A. Alhakamy Prashant Kesharwani Rambabu Dandela
author_sort	Ravi Kumar Bandaru
title	Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
title_short	Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
title_full	Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
title_fullStr	Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
title_full_unstemmed	Recent Advances in Pharmaceutical Cocrystals: From Bench to Market
title_sort	recent advances in pharmaceutical cocrystals: from bench to market
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7d35712f470145e8b50ff89ea57c7fc8
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Recent Advances in Pharmaceutical Cocrystals: From Bench to Market

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