Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synthesis and consumption are lowered during mitosis.

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Autores principales:	Joon Ho Kang, Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim, Matthew G. Vander Heiden, Michael B. Yaffe, Scott R. Manalis, Teemu P. Miettinen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b
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spelling	oai:doaj.org-article:7d36fb2261454301970a2d8ba6a0530b2021-12-02T18:37:17ZMonitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division10.1038/s41467-020-18769-y2041-1723https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18769-yhttps://doaj.org/toc/2041-1723ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synthesis and consumption are lowered during mitosis.Joon Ho KangGeorgios KatsikisZhaoqi LiKiera M. SappMax A. StockslagerDaniel LimMatthew G. Vander HeidenMichael B. YaffeScott R. ManalisTeemu P. MiettinenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joon Ho Kang Georgios Katsikis Zhaoqi Li Kiera M. Sapp Max A. Stockslager Daniel Lim Matthew G. Vander Heiden Michael B. Yaffe Scott R. Manalis Teemu P. Miettinen Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
description	ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synthesis and consumption are lowered during mitosis.
format	article
author	Joon Ho Kang Georgios Katsikis Zhaoqi Li Kiera M. Sapp Max A. Stockslager Daniel Lim Matthew G. Vander Heiden Michael B. Yaffe Scott R. Manalis Teemu P. Miettinen
author_facet	Joon Ho Kang Georgios Katsikis Zhaoqi Li Kiera M. Sapp Max A. Stockslager Daniel Lim Matthew G. Vander Heiden Michael B. Yaffe Scott R. Manalis Teemu P. Miettinen
author_sort	Joon Ho Kang
title	Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
title_short	Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
title_full	Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
title_fullStr	Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
title_full_unstemmed	Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
title_sort	monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased atp synthesis during cell division
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b
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Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division

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