The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study

Rafał Marciniak,1,2 Rastislav &Scaron;umec,1,3,4 Martin Vyhnálek,1 Kamila Bendíčková,5 Petra Lázničková,5,6 Giancarlo Forte,5 Andrej Jeleník,1 Veronika Římalová,1,7 Jan Frič,5 Jakub Hort,1 Kateřina Sheardov&a...

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Autores principales:	Marciniak R, Šumec R, Vyhnálek M, Bendíčková K, Lázničková P, Forte G, Jeleník A, Římalová V, Frič J, Hort J, Sheardová K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cognition depression anxiety mci neurodegeneration monocyte activation Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7d3bc19b10ad46c2b3418245230414e7
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spelling	oai:doaj.org-article:7d3bc19b10ad46c2b3418245230414e72021-12-02T11:03:52ZThe Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study1178-1998https://doaj.org/article/7d3bc19b10ad46c2b3418245230414e72020-08-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-co-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rafał Marciniak,1,2 Rastislav &Scaron;umec,1,3,4 Martin Vyhnálek,1 Kamila Bendíčková,5 Petra Lázničková,5,6 Giancarlo Forte,5 Andrej Jeleník,1 Veronika Římalová,1,7 Jan Frič,5 Jakub Hort,1 Kateřina Sheardová1,3 1International Clinical Research Center (ICRC), St. Anne’s University Hospital, Brno, Czech Republic; 2Department of Psychology, Faculty of Social Studies, Masaryk University, Brno, Czech Republic; 3First Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic; 4Department of Psychology and Psychosomatics, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 5Center of Translational Medicine, International Clinical Research Center (ICRC), St. Anne’s University Hospital, Brno, Czech Republic; 6Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 7Department of Mathematical Analysis and Applications of Mathematics, Faculty of Science, Palacky University Olomouc, Olomouc, Czech RepublicCorrespondence: Rafał MarciniakInternational Clinical Research Center (ICRC), St. Anne’s University Hospital, Pekařská 53, Brno 656 91, Czech RepublicTel +420 736432470Email rafal.marciniaq@gmail.comBackground: Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups.Objective: To determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training.Methods: Twenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2.Results: Twenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition – a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT≤ 36) was associated with the lower adherence to home practice.Conclusion: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile.Keywords: cognition, depression, anxiety, MCI, neurodegeneration, monocyte activationMarciniak RŠumec RVyhnálek MBendíčková KLázničková PForte GJeleník AŘímalová VFrič JHort JSheardová KDove Medical Pressarticlecognitiondepressionanxietymcineurodegenerationmonocyte activationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 1365-1381 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognition depression anxiety mci neurodegeneration monocyte activation Geriatrics RC952-954.6
spellingShingle	cognition depression anxiety mci neurodegeneration monocyte activation Geriatrics RC952-954.6 Marciniak R Šumec R Vyhnálek M Bendíčková K Lázničková P Forte G Jeleník A Římalová V Frič J Hort J Sheardová K The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
description	Rafał Marciniak,1,2 Rastislav &Scaron;umec,1,3,4 Martin Vyhnálek,1 Kamila Bendíčková,5 Petra Lázničková,5,6 Giancarlo Forte,5 Andrej Jeleník,1 Veronika Římalová,1,7 Jan Frič,5 Jakub Hort,1 Kateřina Sheardová1,3 1International Clinical Research Center (ICRC), St. Anne’s University Hospital, Brno, Czech Republic; 2Department of Psychology, Faculty of Social Studies, Masaryk University, Brno, Czech Republic; 3First Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital, Brno, Czech Republic; 4Department of Psychology and Psychosomatics, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 5Center of Translational Medicine, International Clinical Research Center (ICRC), St. Anne’s University Hospital, Brno, Czech Republic; 6Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 7Department of Mathematical Analysis and Applications of Mathematics, Faculty of Science, Palacky University Olomouc, Olomouc, Czech RepublicCorrespondence: Rafał MarciniakInternational Clinical Research Center (ICRC), St. Anne’s University Hospital, Pekařská 53, Brno 656 91, Czech RepublicTel +420 736432470Email rafal.marciniaq@gmail.comBackground: Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups.Objective: To determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training.Methods: Twenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2.Results: Twenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition – a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT≤ 36) was associated with the lower adherence to home practice.Conclusion: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile.Keywords: cognition, depression, anxiety, MCI, neurodegeneration, monocyte activation
format	article
author	Marciniak R Šumec R Vyhnálek M Bendíčková K Lázničková P Forte G Jeleník A Římalová V Frič J Hort J Sheardová K
author_facet	Marciniak R Šumec R Vyhnálek M Bendíčková K Lázničková P Forte G Jeleník A Římalová V Frič J Hort J Sheardová K
author_sort	Marciniak R
title	The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
title_short	The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
title_full	The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
title_fullStr	The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
title_full_unstemmed	The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
title_sort	effect of mindfulness-based stress reduction (mbsr) on depression, cognition, and immunity in mild cognitive impairment: a pilot feasibility study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7d3bc19b10ad46c2b3418245230414e7
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The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study

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