DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE

Worldwide, antimicrobials are widely used in food producing animals for treatment and/or prophylaxis of diseases. In Tanzania, irrational administration of antimicrobials, notably oxytetracycline (OTC) is common because of the under-developed animal health service delivery system. The administration...

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Autores principales:	Engelbert BILASHOBOKA, Boyd MUDENDA, Nosiku MUNYINDA, Fabiola VINCENT MOSHI, Dominic M. KAMBARAGE
Formato:	article
Lenguaje:	EN
Publicado:	Stefan cel Mare University of Suceava 2018
Materias:	toxic/anaphylactic reactions public health threat antibiotic resistant strain of bacteria beef value chain actors Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/7d3e0bcde8814c019eb3e95f8248af9d
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spelling	oai:doaj.org-article:7d3e0bcde8814c019eb3e95f8248af9d2021-12-02T19:27:31ZDETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE2068-66092559-6381https://doaj.org/article/7d3e0bcde8814c019eb3e95f8248af9d2018-12-01T00:00:00Zhttp://www.fia.usv.ro/fiajournal/index.php/FENS/article/view/616/578https://doaj.org/toc/2068-6609https://doaj.org/toc/2559-6381Worldwide, antimicrobials are widely used in food producing animals for treatment and/or prophylaxis of diseases. In Tanzania, irrational administration of antimicrobials, notably oxytetracycline (OTC) is common because of the under-developed animal health service delivery system. The administration of OTC and other drugs is often done by animal keepers, thereby leading to drug residues in meat and milk. The study established the level of OTC residues in edible tissues of cattle slaughtered within Dodoma City Tanzania. This was cross-sectional analytical study design which quantified drug residues in muscle, liver, kidney from licenced and unlicenced premises. Samples from licenced as well as unlicenced premises were collected and used in determining OTC levels using High Performance Liquid Chromatography (HPLC) method. The HPLC method was validated to establish the reliability of the method in quantifying OTC residues. The results indicated that OTC residues were 0.6 mg/kg, 0.25mg/Kg and 1.28 mg/kg for muscle, liver and kidney tissues, respectively against corresponding Maximum Residue Limit (MRL) 0.2mg/kg, 0.6mg/kg and 1.2mg/kg. Regardless of the licensure status and source of the sample, 53% of muscle, 65% of liver and 7.1% of kidney tissues were above MRL. The quantities of OTC residues in samples from licensed and unlicensed food vending settings were not significantly different (p = 0.3676) but above the MRL. The above results show unacceptably high levels of OTC residues in meat with most beef value chain actors being ignorant of the impending public health threat/risks of consuming beef with high drug residues.Engelbert BILASHOBOKABoyd MUDENDANosiku MUNYINDAFabiola VINCENT MOSHIDominic M. KAMBARAGEStefan cel Mare University of Suceavaarticletoxic/anaphylactic reactionspublic health threatantibiotic resistant strain of bacteriabeef value chain actorsFood processing and manufactureTP368-456ENFood and Environment Safety, Vol 17, Iss 4, Pp 404 - 412 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	toxic/anaphylactic reactions public health threat antibiotic resistant strain of bacteria beef value chain actors Food processing and manufacture TP368-456
spellingShingle	toxic/anaphylactic reactions public health threat antibiotic resistant strain of bacteria beef value chain actors Food processing and manufacture TP368-456 Engelbert BILASHOBOKA Boyd MUDENDA Nosiku MUNYINDA Fabiola VINCENT MOSHI Dominic M. KAMBARAGE DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE
description	Worldwide, antimicrobials are widely used in food producing animals for treatment and/or prophylaxis of diseases. In Tanzania, irrational administration of antimicrobials, notably oxytetracycline (OTC) is common because of the under-developed animal health service delivery system. The administration of OTC and other drugs is often done by animal keepers, thereby leading to drug residues in meat and milk. The study established the level of OTC residues in edible tissues of cattle slaughtered within Dodoma City Tanzania. This was cross-sectional analytical study design which quantified drug residues in muscle, liver, kidney from licenced and unlicenced premises. Samples from licenced as well as unlicenced premises were collected and used in determining OTC levels using High Performance Liquid Chromatography (HPLC) method. The HPLC method was validated to establish the reliability of the method in quantifying OTC residues. The results indicated that OTC residues were 0.6 mg/kg, 0.25mg/Kg and 1.28 mg/kg for muscle, liver and kidney tissues, respectively against corresponding Maximum Residue Limit (MRL) 0.2mg/kg, 0.6mg/kg and 1.2mg/kg. Regardless of the licensure status and source of the sample, 53% of muscle, 65% of liver and 7.1% of kidney tissues were above MRL. The quantities of OTC residues in samples from licensed and unlicensed food vending settings were not significantly different (p = 0.3676) but above the MRL. The above results show unacceptably high levels of OTC residues in meat with most beef value chain actors being ignorant of the impending public health threat/risks of consuming beef with high drug residues.
format	article
author	Engelbert BILASHOBOKA Boyd MUDENDA Nosiku MUNYINDA Fabiola VINCENT MOSHI Dominic M. KAMBARAGE
author_facet	Engelbert BILASHOBOKA Boyd MUDENDA Nosiku MUNYINDA Fabiola VINCENT MOSHI Dominic M. KAMBARAGE
author_sort	Engelbert BILASHOBOKA
title	DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE
title_short	DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE
title_full	DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE
title_fullStr	DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE
title_full_unstemmed	DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE
title_sort	determination of oxytetracycline residue levels in edible tissues of slaughtered cattle
publisher	Stefan cel Mare University of Suceava
publishDate	2018
url	https://doaj.org/article/7d3e0bcde8814c019eb3e95f8248af9d
work_keys_str_mv	AT engelbertbilashoboka determinationofoxytetracyclineresiduelevelsinedibletissuesofslaughteredcattle AT boydmudenda determinationofoxytetracyclineresiduelevelsinedibletissuesofslaughteredcattle AT nosikumunyinda determinationofoxytetracyclineresiduelevelsinedibletissuesofslaughteredcattle AT fabiolavincentmoshi determinationofoxytetracyclineresiduelevelsinedibletissuesofslaughteredcattle AT dominicmkambarage determinationofoxytetracyclineresiduelevelsinedibletissuesofslaughteredcattle
_version_	1718376508004761600

DETERMINATION OF OXYTETRACYCLINE RESIDUE LEVELS IN EDIBLE TISSUES OF SLAUGHTERED CATTLE

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