Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis

Abstract Background Varicella is a highly contagious infection that typically occurs in childhood. While most cases have a generally benign outcome, infection results in a considerable healthcare burden and serious complications may occur. Objectives The objective of this study was to characterize t...

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Autores principales:	Jessica Vandenhaute, Elyonore Tsakeu, Pierre Chevalier, Manjiri Pawaskar, Goran Benčina, Jan Vertriest
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Antibiotics Varicella Complications Primary care Burden of varicella Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/7d3e93f988ad41ceaf1564b6652b4f06
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spelling	oai:doaj.org-article:7d3e93f988ad41ceaf1564b6652b4f062021-11-14T12:44:27ZAssessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis10.1186/s12879-021-06848-41471-2334https://doaj.org/article/7d3e93f988ad41ceaf1564b6652b4f062021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06848-4https://doaj.org/toc/1471-2334Abstract Background Varicella is a highly contagious infection that typically occurs in childhood. While most cases have a generally benign outcome, infection results in a considerable healthcare burden and serious complications may occur. Objectives The objective of this study was to characterize the burden of varicella in a real-world primary care setting in Belgium, including the rate of varicella-related complications, medication management and general practitioner (GP) visits. Methods The study was a retrospective observational study using data from a longitudinal patient database in a primary care setting in Belgium. Patients with a GP visit and a varicella diagnosis between January 2016 and June 2019 were eligible and data one month prior and three months after the diagnosis were included. Outcomes included varicella-related complications, antibiotic use, antiviral use, and GP follow-up visits. Antibiotic use could be specified by class of antibiotic and linked to a diagnosis. Complications were identified based on concomitant diagnosis with varicella during the study period. Results 3,847 patients with diagnosis of varicella were included, with a mean age of 8.4 years and a comparable distribution of gender. 12.6% of patients with varicella had a concomitant diagnosis of a varicella-related complication. During the follow-up period, 27.3% of patients with varicella were prescribed antibiotics, either systemic (19.8%) and/or topical (10.3%). The highest rate of antibiotic prescriptions was observed in patients with complications (63.5%) and in patients younger than 1 year (41.8%). Nevertheless, 5.3% of the patients were prescribed antibiotics without a concomitant diagnosis of another infection. The most commonly prescribed systemic antibiotics were amoxicillin alone or combined with beta-lactamase inhibitor, and thiamphenicol. Fusidic acid and tobramycin were the most prescribed topical antibiotics. Antivirals were prescribed for 2.7% of the study population. 4.7% of the patients needed a follow-up visit with their GP. Conclusions This study reports a substantial burden of varicella in a primary care setting in Belgium, with high rates of complications and antibiotic use.Jessica VandenhauteElyonore TsakeuPierre ChevalierManjiri PawaskarGoran BenčinaJan VertriestBMCarticleAntibioticsVaricellaComplicationsPrimary careBurden of varicellaInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibiotics Varicella Complications Primary care Burden of varicella Infectious and parasitic diseases RC109-216
spellingShingle	Antibiotics Varicella Complications Primary care Burden of varicella Infectious and parasitic diseases RC109-216 Jessica Vandenhaute Elyonore Tsakeu Pierre Chevalier Manjiri Pawaskar Goran Benčina Jan Vertriest Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis
description	Abstract Background Varicella is a highly contagious infection that typically occurs in childhood. While most cases have a generally benign outcome, infection results in a considerable healthcare burden and serious complications may occur. Objectives The objective of this study was to characterize the burden of varicella in a real-world primary care setting in Belgium, including the rate of varicella-related complications, medication management and general practitioner (GP) visits. Methods The study was a retrospective observational study using data from a longitudinal patient database in a primary care setting in Belgium. Patients with a GP visit and a varicella diagnosis between January 2016 and June 2019 were eligible and data one month prior and three months after the diagnosis were included. Outcomes included varicella-related complications, antibiotic use, antiviral use, and GP follow-up visits. Antibiotic use could be specified by class of antibiotic and linked to a diagnosis. Complications were identified based on concomitant diagnosis with varicella during the study period. Results 3,847 patients with diagnosis of varicella were included, with a mean age of 8.4 years and a comparable distribution of gender. 12.6% of patients with varicella had a concomitant diagnosis of a varicella-related complication. During the follow-up period, 27.3% of patients with varicella were prescribed antibiotics, either systemic (19.8%) and/or topical (10.3%). The highest rate of antibiotic prescriptions was observed in patients with complications (63.5%) and in patients younger than 1 year (41.8%). Nevertheless, 5.3% of the patients were prescribed antibiotics without a concomitant diagnosis of another infection. The most commonly prescribed systemic antibiotics were amoxicillin alone or combined with beta-lactamase inhibitor, and thiamphenicol. Fusidic acid and tobramycin were the most prescribed topical antibiotics. Antivirals were prescribed for 2.7% of the study population. 4.7% of the patients needed a follow-up visit with their GP. Conclusions This study reports a substantial burden of varicella in a primary care setting in Belgium, with high rates of complications and antibiotic use.
format	article
author	Jessica Vandenhaute Elyonore Tsakeu Pierre Chevalier Manjiri Pawaskar Goran Benčina Jan Vertriest
author_facet	Jessica Vandenhaute Elyonore Tsakeu Pierre Chevalier Manjiri Pawaskar Goran Benčina Jan Vertriest
author_sort	Jessica Vandenhaute
title	Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis
title_short	Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis
title_full	Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis
title_fullStr	Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis
title_full_unstemmed	Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis
title_sort	assessing the use of antibiotics and the burden of varicella in belgium using a retrospective gp database analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7d3e93f988ad41ceaf1564b6652b4f06
work_keys_str_mv	AT jessicavandenhaute assessingtheuseofantibioticsandtheburdenofvaricellainbelgiumusingaretrospectivegpdatabaseanalysis AT elyonoretsakeu assessingtheuseofantibioticsandtheburdenofvaricellainbelgiumusingaretrospectivegpdatabaseanalysis AT pierrechevalier assessingtheuseofantibioticsandtheburdenofvaricellainbelgiumusingaretrospectivegpdatabaseanalysis AT manjiripawaskar assessingtheuseofantibioticsandtheburdenofvaricellainbelgiumusingaretrospectivegpdatabaseanalysis AT goranbencina assessingtheuseofantibioticsandtheburdenofvaricellainbelgiumusingaretrospectivegpdatabaseanalysis AT janvertriest assessingtheuseofantibioticsandtheburdenofvaricellainbelgiumusingaretrospectivegpdatabaseanalysis
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Assessing the use of antibiotics and the burden of varicella in Belgium using a retrospective GP database analysis

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