Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation

Abstract Reappraisal of negative memories and experiences is central for mental health and well-being. Deficiency of reappraisal lies at the core of many psychiatric disorders and is a key target for treatment. Here we apply transcranial direct current stimulation (tDCS) to enhance reappraisal of ne...

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Autores principales:	Nadja Doerig, Rosa J. Seinsche, Marius Moisa, Erich Seifritz, Christian C. Ruff, Birgit Kleim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d3ec75c72da4102b221c6cf78c1d173
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spelling	oai:doaj.org-article:7d3ec75c72da4102b221c6cf78c1d1732021-12-02T16:17:33ZEnhancing reappraisal of negative emotional memories with transcranial direct current stimulation10.1038/s41598-021-93647-12045-2322https://doaj.org/article/7d3ec75c72da4102b221c6cf78c1d1732021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93647-1https://doaj.org/toc/2045-2322Abstract Reappraisal of negative memories and experiences is central for mental health and well-being. Deficiency of reappraisal lies at the core of many psychiatric disorders and is a key target for treatment. Here we apply transcranial direct current stimulation (tDCS) to enhance reappraisal of negative emotional memories. In a randomised, sham-controlled, 2 × 2 between-subject and double-blinded study, we applied single sessions of anodal and sham tDCS over the right dorsolateral prefrontal cortex (dlPFC) of 101 healthy participants while reappraising a personal negative memory or engaging in a control task. We hypothesised that (i) reappraisal decreases negative valence, arousal and evaluations of the memory and leads to improved decision making, and (ii) tDCS leads to additional changes in these reappraisal outcomes. In line with these hypotheses, participants’ personal memories were rated as less negative and less arousing following reappraisal. Anodal tDCS during reappraisal was associated with significant short-term reductions in negative valence compared to sham stimulation. Our results indicate that tDCS may enhance some of the effects of reappraisal. If replicated, our findings suggest potential benefits elicited by tDCS stimulation that may help optimise current treatment approaches for psychiatric disorders.Nadja DoerigRosa J. SeinscheMarius MoisaErich SeifritzChristian C. RuffBirgit KleimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadja Doerig Rosa J. Seinsche Marius Moisa Erich Seifritz Christian C. Ruff Birgit Kleim Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
description	Abstract Reappraisal of negative memories and experiences is central for mental health and well-being. Deficiency of reappraisal lies at the core of many psychiatric disorders and is a key target for treatment. Here we apply transcranial direct current stimulation (tDCS) to enhance reappraisal of negative emotional memories. In a randomised, sham-controlled, 2 × 2 between-subject and double-blinded study, we applied single sessions of anodal and sham tDCS over the right dorsolateral prefrontal cortex (dlPFC) of 101 healthy participants while reappraising a personal negative memory or engaging in a control task. We hypothesised that (i) reappraisal decreases negative valence, arousal and evaluations of the memory and leads to improved decision making, and (ii) tDCS leads to additional changes in these reappraisal outcomes. In line with these hypotheses, participants’ personal memories were rated as less negative and less arousing following reappraisal. Anodal tDCS during reappraisal was associated with significant short-term reductions in negative valence compared to sham stimulation. Our results indicate that tDCS may enhance some of the effects of reappraisal. If replicated, our findings suggest potential benefits elicited by tDCS stimulation that may help optimise current treatment approaches for psychiatric disorders.
format	article
author	Nadja Doerig Rosa J. Seinsche Marius Moisa Erich Seifritz Christian C. Ruff Birgit Kleim
author_facet	Nadja Doerig Rosa J. Seinsche Marius Moisa Erich Seifritz Christian C. Ruff Birgit Kleim
author_sort	Nadja Doerig
title	Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
title_short	Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
title_full	Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
title_fullStr	Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
title_full_unstemmed	Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
title_sort	enhancing reappraisal of negative emotional memories with transcranial direct current stimulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d3ec75c72da4102b221c6cf78c1d173
work_keys_str_mv	AT nadjadoerig enhancingreappraisalofnegativeemotionalmemorieswithtranscranialdirectcurrentstimulation AT rosajseinsche enhancingreappraisalofnegativeemotionalmemorieswithtranscranialdirectcurrentstimulation AT mariusmoisa enhancingreappraisalofnegativeemotionalmemorieswithtranscranialdirectcurrentstimulation AT erichseifritz enhancingreappraisalofnegativeemotionalmemorieswithtranscranialdirectcurrentstimulation AT christiancruff enhancingreappraisalofnegativeemotionalmemorieswithtranscranialdirectcurrentstimulation AT birgitkleim enhancingreappraisalofnegativeemotionalmemorieswithtranscranialdirectcurrentstimulation
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Enhancing reappraisal of negative emotional memories with transcranial direct current stimulation

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