Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells

The present obtained experimental results proved that addition of lipoic acid (LA) with its sodium salt in ratio of 0.1ml mole (mM) in the growth media has improved their physiological activities of different cell lines including MDBK, VERO and BHK21. Such cells remained normal for relative longer t...

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Autores principales:	Maha R. Abd El-Fadile, Hussine A.H.M.
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2016
Materias:	cell culture dihydrolipoic acid .lipoic acid vero cell line Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2016.62119 https://doaj.org/article/7d429022cdbb4ffda2aceb1fc6b4c775
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spelling	oai:doaj.org-article:7d429022cdbb4ffda2aceb1fc6b4c7752021-12-02T18:08:27ZRole of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cellshttps://dx.doi.org/10.21608/javs.2016.621191687-40722090-3308https://doaj.org/article/7d429022cdbb4ffda2aceb1fc6b4c7752016-10-01T00:00:00Zhttps://javs.journals.ekb.eg/article_62119.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308The present obtained experimental results proved that addition of lipoic acid (LA) with its sodium salt in ratio of 0.1ml mole (mM) in the growth media has improved their physiological activities of different cell lines including MDBK, VERO and BHK21. Such cells remained normal for relative longer time comparing with the cell culture provided with media without lipoic acid (LA). The improvement of used cell lines was ascribed to the addition of lipoic acid (LA) dihydrolipoic acid, (DHLA) as protein free media supplement. As Lipoic acid (LA) and its dihydrolipoic acid (DHLA) are involved in several aspects of cell energy and amino acid metabolism, as well as in defense against oxidative stress and apoptosis; both components initiated the production of glutathione which antagonizes the oxidative effect of free radicals on cells that harmfully affects cell metabolism .This study is in need to involve more investigation covering other uses of (LA) especially in its Nano form. Maha R. Abd El-FadileHussine A.H.M.Egyptian Society for Animal Managementarticlecell culturedihydrolipoic acid.lipoic acidvero cell lineZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 1, Iss 1, Pp 43-47 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell culture dihydrolipoic acid .lipoic acid vero cell line Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	cell culture dihydrolipoic acid .lipoic acid vero cell line Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Maha R. Abd El-Fadile Hussine A.H.M. Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells
description	The present obtained experimental results proved that addition of lipoic acid (LA) with its sodium salt in ratio of 0.1ml mole (mM) in the growth media has improved their physiological activities of different cell lines including MDBK, VERO and BHK21. Such cells remained normal for relative longer time comparing with the cell culture provided with media without lipoic acid (LA). The improvement of used cell lines was ascribed to the addition of lipoic acid (LA) dihydrolipoic acid, (DHLA) as protein free media supplement. As Lipoic acid (LA) and its dihydrolipoic acid (DHLA) are involved in several aspects of cell energy and amino acid metabolism, as well as in defense against oxidative stress and apoptosis; both components initiated the production of glutathione which antagonizes the oxidative effect of free radicals on cells that harmfully affects cell metabolism .This study is in need to involve more investigation covering other uses of (LA) especially in its Nano form.
format	article
author	Maha R. Abd El-Fadile Hussine A.H.M.
author_facet	Maha R. Abd El-Fadile Hussine A.H.M.
author_sort	Maha R. Abd El-Fadile
title	Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells
title_short	Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells
title_full	Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells
title_fullStr	Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells
title_full_unstemmed	Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells
title_sort	role of lipoic acid (thioctic acid) in improving vitality of different tissue culture cells
publisher	Egyptian Society for Animal Management
publishDate	2016
url	https://dx.doi.org/10.21608/javs.2016.62119 https://doaj.org/article/7d429022cdbb4ffda2aceb1fc6b4c775
work_keys_str_mv	AT maharabdelfadile roleoflipoicacidthiocticacidinimprovingvitalityofdifferenttissueculturecells AT hussineahm roleoflipoicacidthiocticacidinimprovingvitalityofdifferenttissueculturecells
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Role of lipoic acid (Thioctic acid) in improving vitality of different tissue culture cells

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