Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites

Khaled Habiba,1,2 Joel Encarnacion-Rosado,2,3 Kenny Garcia-Pabon,2,4 Juan C Villalobos-Santos,2,5 Vladimir I Makarov,1 Javier A Avalos,2,6 Brad R Weiner,2,7,8 Gerardo Morell1,2,7 1Department of Physics, University of Puerto Rico – Rio Piedras Campus, 2Molecular Sciences Research Center, U...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Habiba K, Encarnacion-Rosado J, Garcia-Pabon K, Villalobos-Santos JC, Makarov VI, Avalos JA, Weiner BR, Morell G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Graphene quantum dots Silver nanoparticles Cancer therapy Drug delivery Photodynamic therapy Nanocomposites Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7d42bff2873d46f1bdc412ad5f71d9a0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7d42bff2873d46f1bdc412ad5f71d9a0
record_format	dspace
spelling	oai:doaj.org-article:7d42bff2873d46f1bdc412ad5f71d9a02021-12-02T01:49:51ZImproving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites1178-2013https://doaj.org/article/7d42bff2873d46f1bdc412ad5f71d9a02015-12-01T00:00:00Zhttps://www.dovepress.com/improving-cytotoxicity-against-cancer-cells-by-chemo-photodynamic-comb-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Khaled Habiba,1,2 Joel Encarnacion-Rosado,2,3 Kenny Garcia-Pabon,2,4 Juan C Villalobos-Santos,2,5 Vladimir I Makarov,1 Javier A Avalos,2,6 Brad R Weiner,2,7,8 Gerardo Morell1,2,7 1Department of Physics, University of Puerto Rico – Rio Piedras Campus, 2Molecular Sciences Research Center, University of Puerto Rico, 3Department of Biology, 4Faculty of Education, University of Puerto Rico – Rio Piedras Campus, San Juan, 5Department of Biology, 6Department of Physics, University of Puerto Rico – Bayamon Campus, Bayamon, 7Institute for Functional Nanomaterials, University of Puerto Rico, 8Department of Chemistry, University of Puerto Rico – Rio Piedras Campus, San Juan, PR, USA Abstract: The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs) were tested as a platform to deliver a chemotherapy drug and a photosensitizer, simultaneously, in chemo-photodynamic therapy against HeLa and DU145 cancer cells in vitro. Ag-GQDs have displayed high efficiency in delivering doxorubicin as a model chemotherapy drug to both cancer cells. The Ag-GQDs exhibited a strong antitumor activity by inducing apoptosis in cancer cells without affecting the viability of normal cells. Moreover, the Ag-GQDs exhibited a cytotoxic effect due to the generation of the reactive singlet oxygen upon 425 nm irradiation, indicating their applicability in photodynamic therapy. In comparison with chemo or photodynamic treatment alone, the combined treatment of Ag-GQDs conjugated with doxorubicin under irradiation with a 425 nm lamp significantly increased the death in DU145 and HeLa. This study suggests Ag-GQDs as a multifunctional and efficient therapeutic system for chemo-photodynamic modalities in cancer therapy. Keywords: multifunctional nanoparticles, silver nanoparticles, cancer therapy, drug delivery, photodynamic therapy, nanocompositesHabiba KEncarnacion-Rosado JGarcia-Pabon KVillalobos-Santos JCMakarov VIAvalos JAWeiner BRMorell GDove Medical PressarticleGraphene quantum dotsSilver nanoparticlesCancer therapyDrug deliveryPhotodynamic therapyNanocompositesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 107-119 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Graphene quantum dots Silver nanoparticles Cancer therapy Drug delivery Photodynamic therapy Nanocomposites Medicine (General) R5-920
spellingShingle	Graphene quantum dots Silver nanoparticles Cancer therapy Drug delivery Photodynamic therapy Nanocomposites Medicine (General) R5-920 Habiba K Encarnacion-Rosado J Garcia-Pabon K Villalobos-Santos JC Makarov VI Avalos JA Weiner BR Morell G Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
description	Khaled Habiba,1,2 Joel Encarnacion-Rosado,2,3 Kenny Garcia-Pabon,2,4 Juan C Villalobos-Santos,2,5 Vladimir I Makarov,1 Javier A Avalos,2,6 Brad R Weiner,2,7,8 Gerardo Morell1,2,7 1Department of Physics, University of Puerto Rico – Rio Piedras Campus, 2Molecular Sciences Research Center, University of Puerto Rico, 3Department of Biology, 4Faculty of Education, University of Puerto Rico – Rio Piedras Campus, San Juan, 5Department of Biology, 6Department of Physics, University of Puerto Rico – Bayamon Campus, Bayamon, 7Institute for Functional Nanomaterials, University of Puerto Rico, 8Department of Chemistry, University of Puerto Rico – Rio Piedras Campus, San Juan, PR, USA Abstract: The combination of chemotherapy and photodynamic therapy has emerged as a promising strategy for cancer therapy due to its synergistic effects. In this work, PEGylated silver nanoparticles decorated with graphene quantum dots (Ag-GQDs) were tested as a platform to deliver a chemotherapy drug and a photosensitizer, simultaneously, in chemo-photodynamic therapy against HeLa and DU145 cancer cells in vitro. Ag-GQDs have displayed high efficiency in delivering doxorubicin as a model chemotherapy drug to both cancer cells. The Ag-GQDs exhibited a strong antitumor activity by inducing apoptosis in cancer cells without affecting the viability of normal cells. Moreover, the Ag-GQDs exhibited a cytotoxic effect due to the generation of the reactive singlet oxygen upon 425 nm irradiation, indicating their applicability in photodynamic therapy. In comparison with chemo or photodynamic treatment alone, the combined treatment of Ag-GQDs conjugated with doxorubicin under irradiation with a 425 nm lamp significantly increased the death in DU145 and HeLa. This study suggests Ag-GQDs as a multifunctional and efficient therapeutic system for chemo-photodynamic modalities in cancer therapy. Keywords: multifunctional nanoparticles, silver nanoparticles, cancer therapy, drug delivery, photodynamic therapy, nanocomposites
format	article
author	Habiba K Encarnacion-Rosado J Garcia-Pabon K Villalobos-Santos JC Makarov VI Avalos JA Weiner BR Morell G
author_facet	Habiba K Encarnacion-Rosado J Garcia-Pabon K Villalobos-Santos JC Makarov VI Avalos JA Weiner BR Morell G
author_sort	Habiba K
title	Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
title_short	Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
title_full	Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
title_fullStr	Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
title_full_unstemmed	Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
title_sort	improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/7d42bff2873d46f1bdc412ad5f71d9a0
work_keys_str_mv	AT habibak improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT encarnacionrosadoj improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT garciapabonk improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT villalobossantosjc improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT makarovvi improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT avalosja improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT weinerbr improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites AT morellg improvingcytotoxicityagainstcancercellsbychemophotodynamiccombinedmodalitiesusingsilvergraphenequantumdotsnanocomposites
_version_	1718402848747683840

Improving cytotoxicity against cancer cells by chemo-photodynamic combined modalities using silver-graphene quantum dots nanocomposites

Ejemplares similares