Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging

Abstract It is critical to distinguish between cardiac tumors and thrombi because they require different treatment strategies. Although accurate differentiation of these cardiac masses can be challenging, computed tomography (CT) and magnetic resonance imaging (MRI) are promising tools to improve th...

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Autores principales:	Yoo Jin Hong, Jin Hur, Kyunghwa Han, Dong Jin Im, Young Joo Suh, Hye-Jeong Lee, Young Jin Kim, Byoung Wook Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Cardiac Mass Cardiac Tumors Mean Iodine Concentration Thrombus Group Late Gadolinium Enhancement (LGE) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d446b4a0b4244b2a9eafc6ad3e28ebb
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spelling	oai:doaj.org-article:7d446b4a0b4244b2a9eafc6ad3e28ebb2021-12-02T15:08:44ZQuantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging10.1038/s41598-018-33635-02045-2322https://doaj.org/article/7d446b4a0b4244b2a9eafc6ad3e28ebb2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33635-0https://doaj.org/toc/2045-2322Abstract It is critical to distinguish between cardiac tumors and thrombi because they require different treatment strategies. Although accurate differentiation of these cardiac masses can be challenging, computed tomography (CT) and magnetic resonance imaging (MRI) are promising tools to improve their diagnosis. This study aimed to assess the diagnostic value of a volume-based quantification strategy using dual-energy CT to differentiate between cardiac tumors and thrombi. We prospectively enrolled 41 patients who had a cardiac mass. All patients underwent electrocardiography gated dual-energy CT. Among them, 28 patients underwent late gadolinium enhancement cardiac MRI. For quantitative analysis, the following parameters of the entire cardiac masses were measured: CT attenuation values in Hounsfield units (HU), iodine concentration (mg/ml), and signal intensity (SI) ratio. A mixed effects model was used to evaluate the significance of differences in mean CT attenuation, mean iodine concentration, and SI ratios between the cardiac tumor and thrombus groups. Diagnostic performance of each parameter was evaluated by constructing a receiver operating characteristics curve. A total of 24 cardiac tumors and 19 cardiac thrombi were analyzed. The mean iodine concentration was significantly higher in tumors than in thrombi (tumors: 2.98 ± 0.23; thrombi: 1.79 ± 0.26, p = 0.002). The diagnostic performance of iodine concentration was better than that of post-contrast HU (area under the curve [AUC]: 0.77 vs. 0.51; p < 0.001), and worse than that of SI ratio (AUC: 0.89; p = 0.04) for differentiation of cardiac tumors and thrombi. Dual-energy CT using volume-based iodine measurements can differentiate between cardiac tumors and thrombi.Yoo Jin HongJin HurKyunghwa HanDong Jin ImYoung Joo SuhHye-Jeong LeeYoung Jin KimByoung Wook ChoiNature PortfolioarticleCardiac MassCardiac TumorsMean Iodine ConcentrationThrombus GroupLate Gadolinium Enhancement (LGE)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiac Mass Cardiac Tumors Mean Iodine Concentration Thrombus Group Late Gadolinium Enhancement (LGE) Medicine R Science Q
spellingShingle	Cardiac Mass Cardiac Tumors Mean Iodine Concentration Thrombus Group Late Gadolinium Enhancement (LGE) Medicine R Science Q Yoo Jin Hong Jin Hur Kyunghwa Han Dong Jin Im Young Joo Suh Hye-Jeong Lee Young Jin Kim Byoung Wook Choi Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging
description	Abstract It is critical to distinguish between cardiac tumors and thrombi because they require different treatment strategies. Although accurate differentiation of these cardiac masses can be challenging, computed tomography (CT) and magnetic resonance imaging (MRI) are promising tools to improve their diagnosis. This study aimed to assess the diagnostic value of a volume-based quantification strategy using dual-energy CT to differentiate between cardiac tumors and thrombi. We prospectively enrolled 41 patients who had a cardiac mass. All patients underwent electrocardiography gated dual-energy CT. Among them, 28 patients underwent late gadolinium enhancement cardiac MRI. For quantitative analysis, the following parameters of the entire cardiac masses were measured: CT attenuation values in Hounsfield units (HU), iodine concentration (mg/ml), and signal intensity (SI) ratio. A mixed effects model was used to evaluate the significance of differences in mean CT attenuation, mean iodine concentration, and SI ratios between the cardiac tumor and thrombus groups. Diagnostic performance of each parameter was evaluated by constructing a receiver operating characteristics curve. A total of 24 cardiac tumors and 19 cardiac thrombi were analyzed. The mean iodine concentration was significantly higher in tumors than in thrombi (tumors: 2.98 ± 0.23; thrombi: 1.79 ± 0.26, p = 0.002). The diagnostic performance of iodine concentration was better than that of post-contrast HU (area under the curve [AUC]: 0.77 vs. 0.51; p < 0.001), and worse than that of SI ratio (AUC: 0.89; p = 0.04) for differentiation of cardiac tumors and thrombi. Dual-energy CT using volume-based iodine measurements can differentiate between cardiac tumors and thrombi.
format	article
author	Yoo Jin Hong Jin Hur Kyunghwa Han Dong Jin Im Young Joo Suh Hye-Jeong Lee Young Jin Kim Byoung Wook Choi
author_facet	Yoo Jin Hong Jin Hur Kyunghwa Han Dong Jin Im Young Joo Suh Hye-Jeong Lee Young Jin Kim Byoung Wook Choi
author_sort	Yoo Jin Hong
title	Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging
title_short	Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging
title_full	Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging
title_fullStr	Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging
title_full_unstemmed	Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging
title_sort	quantitative analysis of a whole cardiac mass using dual-energy computed tomography: comparison with conventional computed tomography and magnetic resonance imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7d446b4a0b4244b2a9eafc6ad3e28ebb
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Quantitative Analysis of a Whole Cardiac Mass Using Dual-Energy Computed Tomography: Comparison with Conventional Computed Tomography and Magnetic Resonance Imaging

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