De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation

Dwivedy and Ashraf et al. use a hisD knockout strain of M. tuberculosis to show that the mouse immune system controls and eliminates the hisD knockout strain by inducing an IFNγ-dependent depletion of host histidine. These results suggest a link between histidine metabolism and the pathogenesis of M...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abhisek Dwivedy, Anam Ashraf, Bhavya Jha, Deepak Kumar, Nisheeth Agarwal, Bichitra K. Biswal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7d47e0c235c843a1813bce3b53c64a6f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7d47e0c235c843a1813bce3b53c64a6f
record_format	dspace
spelling	oai:doaj.org-article:7d47e0c235c843a1813bce3b53c64a6f2021-12-02T13:24:13ZDe novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation10.1038/s42003-021-01926-42399-3642https://doaj.org/article/7d47e0c235c843a1813bce3b53c64a6f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01926-4https://doaj.org/toc/2399-3642Dwivedy and Ashraf et al. use a hisD knockout strain of M. tuberculosis to show that the mouse immune system controls and eliminates the hisD knockout strain by inducing an IFNγ-dependent depletion of host histidine. These results suggest a link between histidine metabolism and the pathogenesis of M. tuberculosis infection.Abhisek DwivedyAnam AshrafBhavya JhaDeepak KumarNisheeth AgarwalBichitra K. BiswalNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Abhisek Dwivedy Anam Ashraf Bhavya Jha Deepak Kumar Nisheeth Agarwal Bichitra K. Biswal De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
description	Dwivedy and Ashraf et al. use a hisD knockout strain of M. tuberculosis to show that the mouse immune system controls and eliminates the hisD knockout strain by inducing an IFNγ-dependent depletion of host histidine. These results suggest a link between histidine metabolism and the pathogenesis of M. tuberculosis infection.
format	article
author	Abhisek Dwivedy Anam Ashraf Bhavya Jha Deepak Kumar Nisheeth Agarwal Bichitra K. Biswal
author_facet	Abhisek Dwivedy Anam Ashraf Bhavya Jha Deepak Kumar Nisheeth Agarwal Bichitra K. Biswal
author_sort	Abhisek Dwivedy
title	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
title_short	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
title_full	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
title_fullStr	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
title_full_unstemmed	De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation
title_sort	de novo histidine biosynthesis protects mycobacterium tuberculosis from host ifn-γ mediated histidine starvation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d47e0c235c843a1813bce3b53c64a6f
work_keys_str_mv	AT abhisekdwivedy denovohistidinebiosynthesisprotectsmycobacteriumtuberculosisfromhostifngmediatedhistidinestarvation AT anamashraf denovohistidinebiosynthesisprotectsmycobacteriumtuberculosisfromhostifngmediatedhistidinestarvation AT bhavyajha denovohistidinebiosynthesisprotectsmycobacteriumtuberculosisfromhostifngmediatedhistidinestarvation AT deepakkumar denovohistidinebiosynthesisprotectsmycobacteriumtuberculosisfromhostifngmediatedhistidinestarvation AT nisheethagarwal denovohistidinebiosynthesisprotectsmycobacteriumtuberculosisfromhostifngmediatedhistidinestarvation AT bichitrakbiswal denovohistidinebiosynthesisprotectsmycobacteriumtuberculosisfromhostifngmediatedhistidinestarvation
_version_	1718393103434383360

De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation

Ejemplares similares