Cerebral functional networks during sleep in young and older individuals

Abstract Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences...

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Autores principales:	Véronique Daneault, Pierre Orban, Nicolas Martin, Christian Dansereau, Jonathan Godbout, Philippe Pouliot, Philip Dickinson, Nadia Gosselin, Gilles Vandewalle, Pierre Maquet, Jean-Marc Lina, Julien Doyon, Pierre Bellec, Julie Carrier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d4ad7bf82774edebc6778b3fc7fa9ff
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spelling	oai:doaj.org-article:7d4ad7bf82774edebc6778b3fc7fa9ff2021-12-02T15:53:02ZCerebral functional networks during sleep in young and older individuals10.1038/s41598-021-84417-02045-2322https://doaj.org/article/7d4ad7bf82774edebc6778b3fc7fa9ff2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84417-0https://doaj.org/toc/2045-2322Abstract Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences between wakefulness and light sleep stages (N1 and N2 stages) in 16 young (23.1 ± 3.3y; 7 women), and 14 older individuals (59.6 ± 5.7y; 8 women). Results revealed extended, distributed (inter-between) and local (intra-within) decreases in network connectivity during sleep both in young and older individuals. However, compared to the young participants, older individuals showed lower decreases in connectivity or even increases in connectivity between thalamus/basal ganglia and several cerebral regions as well as between frontal regions of various networks. These findings reflect a reduced ability of the older brain to disconnect during sleep that may impede optimal disengagement for loss of responsiveness, enhanced lighter and fragmented sleep, and contribute to age effects on sleep-dependent brain plasticity.Véronique DaneaultPierre OrbanNicolas MartinChristian DansereauJonathan GodboutPhilippe PouliotPhilip DickinsonNadia GosselinGilles VandewallePierre MaquetJean-Marc LinaJulien DoyonPierre BellecJulie CarrierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Véronique Daneault Pierre Orban Nicolas Martin Christian Dansereau Jonathan Godbout Philippe Pouliot Philip Dickinson Nadia Gosselin Gilles Vandewalle Pierre Maquet Jean-Marc Lina Julien Doyon Pierre Bellec Julie Carrier Cerebral functional networks during sleep in young and older individuals
description	Abstract Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences between wakefulness and light sleep stages (N1 and N2 stages) in 16 young (23.1 ± 3.3y; 7 women), and 14 older individuals (59.6 ± 5.7y; 8 women). Results revealed extended, distributed (inter-between) and local (intra-within) decreases in network connectivity during sleep both in young and older individuals. However, compared to the young participants, older individuals showed lower decreases in connectivity or even increases in connectivity between thalamus/basal ganglia and several cerebral regions as well as between frontal regions of various networks. These findings reflect a reduced ability of the older brain to disconnect during sleep that may impede optimal disengagement for loss of responsiveness, enhanced lighter and fragmented sleep, and contribute to age effects on sleep-dependent brain plasticity.
format	article
author	Véronique Daneault Pierre Orban Nicolas Martin Christian Dansereau Jonathan Godbout Philippe Pouliot Philip Dickinson Nadia Gosselin Gilles Vandewalle Pierre Maquet Jean-Marc Lina Julien Doyon Pierre Bellec Julie Carrier
author_facet	Véronique Daneault Pierre Orban Nicolas Martin Christian Dansereau Jonathan Godbout Philippe Pouliot Philip Dickinson Nadia Gosselin Gilles Vandewalle Pierre Maquet Jean-Marc Lina Julien Doyon Pierre Bellec Julie Carrier
author_sort	Véronique Daneault
title	Cerebral functional networks during sleep in young and older individuals
title_short	Cerebral functional networks during sleep in young and older individuals
title_full	Cerebral functional networks during sleep in young and older individuals
title_fullStr	Cerebral functional networks during sleep in young and older individuals
title_full_unstemmed	Cerebral functional networks during sleep in young and older individuals
title_sort	cerebral functional networks during sleep in young and older individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d4ad7bf82774edebc6778b3fc7fa9ff
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Cerebral functional networks during sleep in young and older individuals

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