Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.

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Detalles Bibliográficos
Autores principales: Pablo Perez-Pinera, Ningren Han, Sara Cleto, Jicong Cao, Oliver Purcell, Kartik A. Shah, Kevin Lee, Rajeev Ram, Timothy K. Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7d4eb34812f54fcf8365ae570daf603d
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Descripción
Sumario:Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.