Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.

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Detalles Bibliográficos
Autores principales:	Pablo Perez-Pinera, Ningren Han, Sara Cleto, Jicong Cao, Oliver Purcell, Kartik A. Shah, Kevin Lee, Rajeev Ram, Timothy K. Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d4eb34812f54fcf8365ae570daf603d
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spelling	oai:doaj.org-article:7d4eb34812f54fcf8365ae570daf603d2021-12-02T15:35:26ZSynthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care10.1038/ncomms122112041-1723https://doaj.org/article/7d4eb34812f54fcf8365ae570daf603d2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12211https://doaj.org/toc/2041-1723Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.Pablo Perez-PineraNingren HanSara CletoJicong CaoOliver PurcellKartik A. ShahKevin LeeRajeev RamTimothy K. LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pablo Perez-Pinera Ningren Han Sara Cleto Jicong Cao Oliver Purcell Kartik A. Shah Kevin Lee Rajeev Ram Timothy K. Lu Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
description	Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.
format	article
author	Pablo Perez-Pinera Ningren Han Sara Cleto Jicong Cao Oliver Purcell Kartik A. Shah Kevin Lee Rajeev Ram Timothy K. Lu
author_facet	Pablo Perez-Pinera Ningren Han Sara Cleto Jicong Cao Oliver Purcell Kartik A. Shah Kevin Lee Rajeev Ram Timothy K. Lu
author_sort	Pablo Perez-Pinera
title	Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
title_short	Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
title_full	Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
title_fullStr	Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
title_full_unstemmed	Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
title_sort	synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7d4eb34812f54fcf8365ae570daf603d
work_keys_str_mv	AT pabloperezpinera syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT ningrenhan syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT saracleto syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT jicongcao syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT oliverpurcell syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT kartikashah syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT kevinlee syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT rajeevram syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare AT timothyklu syntheticbiologyandmicrobioreactorplatformsforprogrammableproductionofbiologicsatthepointofcare
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Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

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