The pial vasculature of the mouse develops according to a sensory-independent program

Abstract The cerebral vasculature is organized to supply the brain’s metabolic needs. Sensory deprivation during the early postnatal period causes altered neural activity and lower metabolic demand. Neural activity is instructional for some aspects of vascular development, and deprivation causes cha...

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Autores principales:	Matthew D. Adams, Aaron T. Winder, Pablo Blinder, Patrick J. Drew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d4ec6dc4e4345b1814d9d80b3d85e28
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spelling	oai:doaj.org-article:7d4ec6dc4e4345b1814d9d80b3d85e282021-12-02T15:09:12ZThe pial vasculature of the mouse develops according to a sensory-independent program10.1038/s41598-018-27910-32045-2322https://doaj.org/article/7d4ec6dc4e4345b1814d9d80b3d85e282018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27910-3https://doaj.org/toc/2045-2322Abstract The cerebral vasculature is organized to supply the brain’s metabolic needs. Sensory deprivation during the early postnatal period causes altered neural activity and lower metabolic demand. Neural activity is instructional for some aspects of vascular development, and deprivation causes changes in capillary density in the deprived brain region. However, it is not known if the pial arteriole network, which contains many leptomeningeal anastomoses (LMAs) that endow the network with redundancy against occlusions, is also affected by sensory deprivation. We quantified the effects of early-life sensory deprivation via whisker plucking on the densities of LMAs and penetrating arterioles (PAs) in anatomically-identified primary sensory regions (vibrissae cortex, forelimb/hindlimb cortex, visual cortex and auditory cortex) in mice. We found that the densities of penetrating arterioles were the same across cortical regions, though the hindlimb representation had a higher density of LMAs than other sensory regions. We found that the densities of PAs and LMAs, as well as quantitative measures of network topology, were not affected by sensory deprivation. Our results show that the postnatal development of the pial arterial network is robust to sensory deprivation.Matthew D. AdamsAaron T. WinderPablo BlinderPatrick J. DrewNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew D. Adams Aaron T. Winder Pablo Blinder Patrick J. Drew The pial vasculature of the mouse develops according to a sensory-independent program
description	Abstract The cerebral vasculature is organized to supply the brain’s metabolic needs. Sensory deprivation during the early postnatal period causes altered neural activity and lower metabolic demand. Neural activity is instructional for some aspects of vascular development, and deprivation causes changes in capillary density in the deprived brain region. However, it is not known if the pial arteriole network, which contains many leptomeningeal anastomoses (LMAs) that endow the network with redundancy against occlusions, is also affected by sensory deprivation. We quantified the effects of early-life sensory deprivation via whisker plucking on the densities of LMAs and penetrating arterioles (PAs) in anatomically-identified primary sensory regions (vibrissae cortex, forelimb/hindlimb cortex, visual cortex and auditory cortex) in mice. We found that the densities of penetrating arterioles were the same across cortical regions, though the hindlimb representation had a higher density of LMAs than other sensory regions. We found that the densities of PAs and LMAs, as well as quantitative measures of network topology, were not affected by sensory deprivation. Our results show that the postnatal development of the pial arterial network is robust to sensory deprivation.
format	article
author	Matthew D. Adams Aaron T. Winder Pablo Blinder Patrick J. Drew
author_facet	Matthew D. Adams Aaron T. Winder Pablo Blinder Patrick J. Drew
author_sort	Matthew D. Adams
title	The pial vasculature of the mouse develops according to a sensory-independent program
title_short	The pial vasculature of the mouse develops according to a sensory-independent program
title_full	The pial vasculature of the mouse develops according to a sensory-independent program
title_fullStr	The pial vasculature of the mouse develops according to a sensory-independent program
title_full_unstemmed	The pial vasculature of the mouse develops according to a sensory-independent program
title_sort	pial vasculature of the mouse develops according to a sensory-independent program
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7d4ec6dc4e4345b1814d9d80b3d85e28
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The pial vasculature of the mouse develops according to a sensory-independent program

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