Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects

Increasing evidence suggested that cholesterol is an important integrant of cell membranes, that plays a key role in tumor progression, immune dysregulation, and pathological changes in epigenetic mechanisms. Based on these theories, there is a growing interest on targeting cholesterol in the treatm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang Xi, Zhou Yani, Mao Jing, Wu Yinhang, Hou Xiaohui, Zhuang Jing, Qi Quan, Han Shuwen
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cholesterol Metabolites Gut microbiome Immune Epigenetic Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7d503ee225d54ed4a7488c02eb663ced
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7d503ee225d54ed4a7488c02eb663ced
record_format	dspace
spelling	oai:doaj.org-article:7d503ee225d54ed4a7488c02eb663ced2021-11-14T04:29:09ZMechanisms of induction of tumors by cholesterol and potential therapeutic prospects0753-332210.1016/j.biopha.2021.112277https://doaj.org/article/7d503ee225d54ed4a7488c02eb663ced2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010611https://doaj.org/toc/0753-3322Increasing evidence suggested that cholesterol is an important integrant of cell membranes, that plays a key role in tumor progression, immune dysregulation, and pathological changes in epigenetic mechanisms. Based on these theories, there is a growing interest on targeting cholesterol in the treatment of cancer. Here, we comprehensively reviewed the major function of cholesterol on oncogenicity, the therapeutic targets of cholesterol and its metabolites in cancer, and provide detailed insight into the essential roles of cholesterol in mediating immune and epigenetic mechanisms of the tumor microenvironment. It is also worth mentioning that the gut microbiome is an indispensable component of cancer mediation because of its role in cholesterol metabolism. Finally, we summarized recent studies on the potential targets of cholesterol and their metabolism, to provide more therapeutic interventions in oncology.Yang XiZhou YaniMao JingWu YinhangHou XiaohuiZhuang JingQi QuanHan ShuwenElsevierarticleCholesterolMetabolitesGut microbiomeImmuneEpigeneticTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112277- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cholesterol Metabolites Gut microbiome Immune Epigenetic Therapeutics. Pharmacology RM1-950
spellingShingle	Cholesterol Metabolites Gut microbiome Immune Epigenetic Therapeutics. Pharmacology RM1-950 Yang Xi Zhou Yani Mao Jing Wu Yinhang Hou Xiaohui Zhuang Jing Qi Quan Han Shuwen Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
description	Increasing evidence suggested that cholesterol is an important integrant of cell membranes, that plays a key role in tumor progression, immune dysregulation, and pathological changes in epigenetic mechanisms. Based on these theories, there is a growing interest on targeting cholesterol in the treatment of cancer. Here, we comprehensively reviewed the major function of cholesterol on oncogenicity, the therapeutic targets of cholesterol and its metabolites in cancer, and provide detailed insight into the essential roles of cholesterol in mediating immune and epigenetic mechanisms of the tumor microenvironment. It is also worth mentioning that the gut microbiome is an indispensable component of cancer mediation because of its role in cholesterol metabolism. Finally, we summarized recent studies on the potential targets of cholesterol and their metabolism, to provide more therapeutic interventions in oncology.
format	article
author	Yang Xi Zhou Yani Mao Jing Wu Yinhang Hou Xiaohui Zhuang Jing Qi Quan Han Shuwen
author_facet	Yang Xi Zhou Yani Mao Jing Wu Yinhang Hou Xiaohui Zhuang Jing Qi Quan Han Shuwen
author_sort	Yang Xi
title	Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
title_short	Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
title_full	Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
title_fullStr	Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
title_full_unstemmed	Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
title_sort	mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7d503ee225d54ed4a7488c02eb663ced
work_keys_str_mv	AT yangxi mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT zhouyani mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT maojing mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT wuyinhang mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT houxiaohui mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT zhuangjing mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT qiquan mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects AT hanshuwen mechanismsofinductionoftumorsbycholesterolandpotentialtherapeuticprospects
_version_	1718430023743963136

Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects

Ejemplares similares