Signatures of white-matter microstructure degradation during aging and its association with cognitive status

Abstract Previous studies have shown an association between cognitive decline and white matter integrity in aging. This led to the formulation of a “disconnection hypothesis” in the aging-brain, which states that the disruption in cortical network communication may explain the cognitive decline duri...

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Autores principales:	Ana Coelho, Henrique M. Fernandes, Ricardo Magalhães, Pedro Silva Moreira, Paulo Marques, José M. Soares, Liliana Amorim, Carlos Portugal-Nunes, Teresa Castanho, Nadine Correia Santos, Nuno Sousa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d57ef2d7be64f59963488c14c1195e3
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spelling	oai:doaj.org-article:7d57ef2d7be64f59963488c14c1195e32021-12-02T13:20:02ZSignatures of white-matter microstructure degradation during aging and its association with cognitive status10.1038/s41598-021-83983-72045-2322https://doaj.org/article/7d57ef2d7be64f59963488c14c1195e32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83983-7https://doaj.org/toc/2045-2322Abstract Previous studies have shown an association between cognitive decline and white matter integrity in aging. This led to the formulation of a “disconnection hypothesis” in the aging-brain, which states that the disruption in cortical network communication may explain the cognitive decline during aging. Although some longitudinal studies have already investigated the changes occurring in white matter microstructure, most focused on specific white matter tracts. Our study aims to characterize the longitudinal whole-brain signatures of white matter microstructural change during aging. Furthermore, we assessed the relationship between distinct longitudinal alterations in white matter integrity and cognition. White matter microstructural properties were estimated from diffusion magnetic resonance imaging, and cognitive status characterized from extensive neurocognitive testing. The same individuals were evaluated at two timepoints, with a mean interval time of 52.8 months (SD = 7.24) between first and last assessment. Our results show that age is associated with a decline in cognitive performance and a degradation in white matter integrity. Additionally, significant associations were found between diffusion measures and different cognitive dimensions (memory, executive function and general cognition). Overall, these results suggest that age-related cognitive decline is related to white matter alterations, and thus give support to the “disconnected hypothesis” of the aging brain.Ana CoelhoHenrique M. FernandesRicardo MagalhãesPedro Silva MoreiraPaulo MarquesJosé M. SoaresLiliana AmorimCarlos Portugal-NunesTeresa CastanhoNadine Correia SantosNuno SousaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ana Coelho Henrique M. Fernandes Ricardo Magalhães Pedro Silva Moreira Paulo Marques José M. Soares Liliana Amorim Carlos Portugal-Nunes Teresa Castanho Nadine Correia Santos Nuno Sousa Signatures of white-matter microstructure degradation during aging and its association with cognitive status
description	Abstract Previous studies have shown an association between cognitive decline and white matter integrity in aging. This led to the formulation of a “disconnection hypothesis” in the aging-brain, which states that the disruption in cortical network communication may explain the cognitive decline during aging. Although some longitudinal studies have already investigated the changes occurring in white matter microstructure, most focused on specific white matter tracts. Our study aims to characterize the longitudinal whole-brain signatures of white matter microstructural change during aging. Furthermore, we assessed the relationship between distinct longitudinal alterations in white matter integrity and cognition. White matter microstructural properties were estimated from diffusion magnetic resonance imaging, and cognitive status characterized from extensive neurocognitive testing. The same individuals were evaluated at two timepoints, with a mean interval time of 52.8 months (SD = 7.24) between first and last assessment. Our results show that age is associated with a decline in cognitive performance and a degradation in white matter integrity. Additionally, significant associations were found between diffusion measures and different cognitive dimensions (memory, executive function and general cognition). Overall, these results suggest that age-related cognitive decline is related to white matter alterations, and thus give support to the “disconnected hypothesis” of the aging brain.
format	article
author	Ana Coelho Henrique M. Fernandes Ricardo Magalhães Pedro Silva Moreira Paulo Marques José M. Soares Liliana Amorim Carlos Portugal-Nunes Teresa Castanho Nadine Correia Santos Nuno Sousa
author_facet	Ana Coelho Henrique M. Fernandes Ricardo Magalhães Pedro Silva Moreira Paulo Marques José M. Soares Liliana Amorim Carlos Portugal-Nunes Teresa Castanho Nadine Correia Santos Nuno Sousa
author_sort	Ana Coelho
title	Signatures of white-matter microstructure degradation during aging and its association with cognitive status
title_short	Signatures of white-matter microstructure degradation during aging and its association with cognitive status
title_full	Signatures of white-matter microstructure degradation during aging and its association with cognitive status
title_fullStr	Signatures of white-matter microstructure degradation during aging and its association with cognitive status
title_full_unstemmed	Signatures of white-matter microstructure degradation during aging and its association with cognitive status
title_sort	signatures of white-matter microstructure degradation during aging and its association with cognitive status
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d57ef2d7be64f59963488c14c1195e3
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Signatures of white-matter microstructure degradation during aging and its association with cognitive status

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