Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease

Abstract Neurovascular coupling can be directly assessed by retinal vessel response to flickering light using optical imaging methods. The response is altered in a number of ocular and cardiovascular diseases. Whether it is altered in Alzheimer’s disease (AD) is investigated. Retinal vessel reaction...

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Autores principales:	Konstantin Kotliar, Christine Hauser, Marion Ortner, Claudia Muggenthaler, Janine Diehl-Schmid, Susanne Angermann, Alexander Hapfelmeier, Christoph Schmaderer, Timo Grimmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d581372368a469f846c34964c59aaad
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spelling	oai:doaj.org-article:7d581372368a469f846c34964c59aaad2021-12-02T15:06:19ZAltered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease10.1038/s41598-017-13349-52045-2322https://doaj.org/article/7d581372368a469f846c34964c59aaad2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-13349-5https://doaj.org/toc/2045-2322Abstract Neurovascular coupling can be directly assessed by retinal vessel response to flickering light using optical imaging methods. The response is altered in a number of ocular and cardiovascular diseases. Whether it is altered in Alzheimer’s disease (AD) is investigated. Retinal vessel reaction to monochromatic flicker stimulation was examined by Dynamic Vessel Analyzer independent of the commercial software in elderly subjects: 15 patients with mild-to-moderate dementia due to AD (ADD); 24 patients with mild cognitive impairment due to AD (MCI); 15 cognitively healthy controls (HC). Retinal vessels in ADD showed a more emphasized and delayed reactive dilation as compared to HC. In MCI, these aspects still differed from those seen in ADD. Maximal arterial reaction was increased and dilation was delayed in ADD as compared to HC (p = 0.004 and p < 0.001) and to MCI (p = 0.058 and p = 0.004), respectively. Maximal venous reaction was increased in ADD as compared to HC (p = 0.001) and to MCI (p = 0.007), respectively. This finding suggests that retinal neuronal activity is either increased or feed-back loop of neurovascular coupling is damaged with differentiating alterations across the spectrum of AD. Thus, retinal vessel reaction to flicker stimulation is considered a promising non-invasive, widely available and easy-to-administer future biomarker for the diagnosis and monitoring of AD.Konstantin KotliarChristine HauserMarion OrtnerClaudia MuggenthalerJanine Diehl-SchmidSusanne AngermannAlexander HapfelmeierChristoph SchmadererTimo GrimmerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Konstantin Kotliar Christine Hauser Marion Ortner Claudia Muggenthaler Janine Diehl-Schmid Susanne Angermann Alexander Hapfelmeier Christoph Schmaderer Timo Grimmer Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
description	Abstract Neurovascular coupling can be directly assessed by retinal vessel response to flickering light using optical imaging methods. The response is altered in a number of ocular and cardiovascular diseases. Whether it is altered in Alzheimer’s disease (AD) is investigated. Retinal vessel reaction to monochromatic flicker stimulation was examined by Dynamic Vessel Analyzer independent of the commercial software in elderly subjects: 15 patients with mild-to-moderate dementia due to AD (ADD); 24 patients with mild cognitive impairment due to AD (MCI); 15 cognitively healthy controls (HC). Retinal vessels in ADD showed a more emphasized and delayed reactive dilation as compared to HC. In MCI, these aspects still differed from those seen in ADD. Maximal arterial reaction was increased and dilation was delayed in ADD as compared to HC (p = 0.004 and p < 0.001) and to MCI (p = 0.058 and p = 0.004), respectively. Maximal venous reaction was increased in ADD as compared to HC (p = 0.001) and to MCI (p = 0.007), respectively. This finding suggests that retinal neuronal activity is either increased or feed-back loop of neurovascular coupling is damaged with differentiating alterations across the spectrum of AD. Thus, retinal vessel reaction to flicker stimulation is considered a promising non-invasive, widely available and easy-to-administer future biomarker for the diagnosis and monitoring of AD.
format	article
author	Konstantin Kotliar Christine Hauser Marion Ortner Claudia Muggenthaler Janine Diehl-Schmid Susanne Angermann Alexander Hapfelmeier Christoph Schmaderer Timo Grimmer
author_facet	Konstantin Kotliar Christine Hauser Marion Ortner Claudia Muggenthaler Janine Diehl-Schmid Susanne Angermann Alexander Hapfelmeier Christoph Schmaderer Timo Grimmer
author_sort	Konstantin Kotliar
title	Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
title_short	Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
title_full	Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
title_fullStr	Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
title_full_unstemmed	Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease
title_sort	altered neurovascular coupling as measured by optical imaging: a biomarker for alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7d581372368a469f846c34964c59aaad
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Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer’s disease

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