Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination

Current SpCas9 adenine base editors that minimise RNA off-target activities have constrained editing windows. Here the authors use domain insertion of TadA into Cas9 to narrow, expand or shift the editing window with RNA off-target minimization simultaneously

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Autores principales:	Shuo Li, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Jiayi Qiu, Xing-Ming Zhao, Xiaolin Wang, Zilong Qiu, Tian-Lin Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d58167fcfff4dcdb6820d39f8718c52
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spelling	oai:doaj.org-article:7d58167fcfff4dcdb6820d39f8718c522021-12-02T15:39:28ZDocking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination10.1038/s41467-020-19730-92041-1723https://doaj.org/article/7d58167fcfff4dcdb6820d39f8718c522020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19730-9https://doaj.org/toc/2041-1723Current SpCas9 adenine base editors that minimise RNA off-target activities have constrained editing windows. Here the authors use domain insertion of TadA into Cas9 to narrow, expand or shift the editing window with RNA off-target minimization simultaneouslyShuo LiBo YuanJixin CaoJingqi ChenJinlong ChenJiayi QiuXing-Ming ZhaoXiaolin WangZilong QiuTian-Lin ChengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuo Li Bo Yuan Jixin Cao Jingqi Chen Jinlong Chen Jiayi Qiu Xing-Ming Zhao Xiaolin Wang Zilong Qiu Tian-Lin Cheng Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
description	Current SpCas9 adenine base editors that minimise RNA off-target activities have constrained editing windows. Here the authors use domain insertion of TadA into Cas9 to narrow, expand or shift the editing window with RNA off-target minimization simultaneously
format	article
author	Shuo Li Bo Yuan Jixin Cao Jingqi Chen Jinlong Chen Jiayi Qiu Xing-Ming Zhao Xiaolin Wang Zilong Qiu Tian-Lin Cheng
author_facet	Shuo Li Bo Yuan Jixin Cao Jingqi Chen Jinlong Chen Jiayi Qiu Xing-Ming Zhao Xiaolin Wang Zilong Qiu Tian-Lin Cheng
author_sort	Shuo Li
title	Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
title_short	Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
title_full	Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
title_fullStr	Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
title_full_unstemmed	Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination
title_sort	docking sites inside cas9 for adenine base editing diversification and rna off-target elimination
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7d58167fcfff4dcdb6820d39f8718c52
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Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination

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