Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination

Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination

Current SpCas9 adenine base editors that minimise RNA off-target activities have constrained editing windows. Here the authors use domain insertion of TadA into Cas9 to narrow, expand or shift the editing window with RNA off-target minimization simultaneously

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Detalles Bibliográficos
Autores principales: Shuo Li, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Jiayi Qiu, Xing-Ming Zhao, Xiaolin Wang, Zilong Qiu, Tian-Lin Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/7d58167fcfff4dcdb6820d39f8718c52
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