Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer

Abstract Background Although multiparametric magnetic resonance imaging (mpMRI) is widely used to assess the volume of prostate cancer, it often underestimates the histological tumor boundary. The aim of this study was to evaluate the feasibility of combining prostate health index (PHI) and mpMRI to...

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Autores principales:	Po-Fan Hsieh, Tzung-Ruei Li, Wei-Ching Lin, Han Chang, Chi-Ping Huang, Chao-Hsiang Chang, Chi-Rei Yang, Chin-Chung Yeh, Wen-Chin Huang, Hsi-Chin Wu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Multiparametric magnetic resonance imaging Prostate cancer Prostate health index Tumor diameter Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/7d58871c0b9548bfb0c929a3da0c4737
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spelling	oai:doaj.org-article:7d58871c0b9548bfb0c929a3da0c47372021-11-21T12:31:01ZCombining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer10.1186/s12894-021-00928-y1471-2490https://doaj.org/article/7d58871c0b9548bfb0c929a3da0c47372021-11-01T00:00:00Zhttps://doi.org/10.1186/s12894-021-00928-yhttps://doaj.org/toc/1471-2490Abstract Background Although multiparametric magnetic resonance imaging (mpMRI) is widely used to assess the volume of prostate cancer, it often underestimates the histological tumor boundary. The aim of this study was to evaluate the feasibility of combining prostate health index (PHI) and mpMRI to estimate the histological tumor diameter and determine the safety margin during treatment of prostate cancer. Methods We retrospectively enrolled 72 prostate cancer patients who underwent radical prostatectomy and had received PHI tests and mpMRI before surgery. We compared the discrepancy between histological and radiological tumor diameter stratified by Prostate Imaging-Reporting and Data System (PI-RADS) score, and then assessed the influence of PHI on the discrepancy between low PI-RADS (2 or 3) and high PI-RADS (4 or 5) groups. Results The mean radiological and histological tumor diameters were 1.60 cm and 2.13 cm, respectively. The median discrepancy between radiological and histological tumor diameter of PI-RADS 4 or 5 lesions was significantly greater than that of PI-RADS 2 or 3 lesions (0.50 cm, IQR (0.00–0.90) vs. 0.00 cm, IQR (−0.10–0.20), p = 0.02). In the low PI-RADS group, the upper limit of the discrepancy was 0.2 cm; so the safety margin could be set at 0.1 cm. In the high PI-RADS group, the upper limits of the discrepancy were 1.2, 1.6, and 2.2 cm in men with PHI < 30, 30–60, and > 60; so the safety margin could be set at 0.6, 0.8, and 1.1 cm, respectively. Conclusions Radiological tumor diameter on mpMRI often underestimated the histological tumor diameter, especially for PI-RADS 4 or 5 lesions. Combining mpMRI and PHI may help to better estimate the histological tumor diameter.Po-Fan HsiehTzung-Ruei LiWei-Ching LinHan ChangChi-Ping HuangChao-Hsiang ChangChi-Rei YangChin-Chung YehWen-Chin HuangHsi-Chin WuBMCarticleMultiparametric magnetic resonance imagingProstate cancerProstate health indexTumor diameterDiseases of the genitourinary system. UrologyRC870-923ENBMC Urology, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiparametric magnetic resonance imaging Prostate cancer Prostate health index Tumor diameter Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Multiparametric magnetic resonance imaging Prostate cancer Prostate health index Tumor diameter Diseases of the genitourinary system. Urology RC870-923 Po-Fan Hsieh Tzung-Ruei Li Wei-Ching Lin Han Chang Chi-Ping Huang Chao-Hsiang Chang Chi-Rei Yang Chin-Chung Yeh Wen-Chin Huang Hsi-Chin Wu Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
description	Abstract Background Although multiparametric magnetic resonance imaging (mpMRI) is widely used to assess the volume of prostate cancer, it often underestimates the histological tumor boundary. The aim of this study was to evaluate the feasibility of combining prostate health index (PHI) and mpMRI to estimate the histological tumor diameter and determine the safety margin during treatment of prostate cancer. Methods We retrospectively enrolled 72 prostate cancer patients who underwent radical prostatectomy and had received PHI tests and mpMRI before surgery. We compared the discrepancy between histological and radiological tumor diameter stratified by Prostate Imaging-Reporting and Data System (PI-RADS) score, and then assessed the influence of PHI on the discrepancy between low PI-RADS (2 or 3) and high PI-RADS (4 or 5) groups. Results The mean radiological and histological tumor diameters were 1.60 cm and 2.13 cm, respectively. The median discrepancy between radiological and histological tumor diameter of PI-RADS 4 or 5 lesions was significantly greater than that of PI-RADS 2 or 3 lesions (0.50 cm, IQR (0.00–0.90) vs. 0.00 cm, IQR (−0.10–0.20), p = 0.02). In the low PI-RADS group, the upper limit of the discrepancy was 0.2 cm; so the safety margin could be set at 0.1 cm. In the high PI-RADS group, the upper limits of the discrepancy were 1.2, 1.6, and 2.2 cm in men with PHI < 30, 30–60, and > 60; so the safety margin could be set at 0.6, 0.8, and 1.1 cm, respectively. Conclusions Radiological tumor diameter on mpMRI often underestimated the histological tumor diameter, especially for PI-RADS 4 or 5 lesions. Combining mpMRI and PHI may help to better estimate the histological tumor diameter.
format	article
author	Po-Fan Hsieh Tzung-Ruei Li Wei-Ching Lin Han Chang Chi-Ping Huang Chao-Hsiang Chang Chi-Rei Yang Chin-Chung Yeh Wen-Chin Huang Hsi-Chin Wu
author_facet	Po-Fan Hsieh Tzung-Ruei Li Wei-Ching Lin Han Chang Chi-Ping Huang Chao-Hsiang Chang Chi-Rei Yang Chin-Chung Yeh Wen-Chin Huang Hsi-Chin Wu
author_sort	Po-Fan Hsieh
title	Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
title_short	Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
title_full	Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
title_fullStr	Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
title_full_unstemmed	Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
title_sort	combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7d58871c0b9548bfb0c929a3da0c4737
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Combining prostate health index and multiparametric magnetic resonance imaging in estimating the histological diameter of prostate cancer

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