JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes

Sakane et al. demonstrate that JRAB/MICAL-L2, an effector protein of Rab8 and Rab13, induces endosomal tubulation in HeLa cells depending on its closed conformation caused by an activated Rab8A. JRAB/MICAL-L2 undergoes liquid-liquid phase separation when overexpressed, which precedes its interaction...

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Autores principales:	Ayuko Sakane, Taka-aki Yano, Takayuki Uchihashi, Kazuki Horikawa, Yusuke Hara, Issei Imoto, Shusaku Kurisu, Hiroshi Yamada, Kohji Takei, Takuya Sasaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7d59caf0ee0141aaa9aefc5a48b29c24
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spelling	oai:doaj.org-article:7d59caf0ee0141aaa9aefc5a48b29c242021-12-02T17:02:05ZJRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes10.1038/s42003-021-02080-72399-3642https://doaj.org/article/7d59caf0ee0141aaa9aefc5a48b29c242021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02080-7https://doaj.org/toc/2399-3642Sakane et al. demonstrate that JRAB/MICAL-L2, an effector protein of Rab8 and Rab13, induces endosomal tubulation in HeLa cells depending on its closed conformation caused by an activated Rab8A. JRAB/MICAL-L2 undergoes liquid-liquid phase separation when overexpressed, which precedes its interaction with Rab8A, eventually leading to tubulation.Ayuko SakaneTaka-aki YanoTakayuki UchihashiKazuki HorikawaYusuke HaraIssei ImotoShusaku KurisuHiroshi YamadaKohji TakeiTakuya SasakiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ayuko Sakane Taka-aki Yano Takayuki Uchihashi Kazuki Horikawa Yusuke Hara Issei Imoto Shusaku Kurisu Hiroshi Yamada Kohji Takei Takuya Sasaki JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
description	Sakane et al. demonstrate that JRAB/MICAL-L2, an effector protein of Rab8 and Rab13, induces endosomal tubulation in HeLa cells depending on its closed conformation caused by an activated Rab8A. JRAB/MICAL-L2 undergoes liquid-liquid phase separation when overexpressed, which precedes its interaction with Rab8A, eventually leading to tubulation.
format	article
author	Ayuko Sakane Taka-aki Yano Takayuki Uchihashi Kazuki Horikawa Yusuke Hara Issei Imoto Shusaku Kurisu Hiroshi Yamada Kohji Takei Takuya Sasaki
author_facet	Ayuko Sakane Taka-aki Yano Takayuki Uchihashi Kazuki Horikawa Yusuke Hara Issei Imoto Shusaku Kurisu Hiroshi Yamada Kohji Takei Takuya Sasaki
author_sort	Ayuko Sakane
title	JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
title_short	JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
title_full	JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
title_fullStr	JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
title_full_unstemmed	JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
title_sort	jrab/mical-l2 undergoes liquid–liquid phase separation to form tubular recycling endosomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d59caf0ee0141aaa9aefc5a48b29c24
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JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes

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