Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

Summary: Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need for Wnts. Here we describe a class o...

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Autores principales:	Bahar Degirmenci, Cansu Dincer, Habibe Cansu Demirel, Linda Berkova, Andreas E. Moor, Abdullah Kahraman, George Hausmann, Michel Aguet, Nurcan Tuncbag, Tomas Valenta, Konrad Basler
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Molecular physiology Immunology Cell biology Cancer Omics Science Q
Acceso en línea:	https://doaj.org/article/7d5fcf03a27a4c14bb1db2d84c671f91
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spelling	oai:doaj.org-article:7d5fcf03a27a4c14bb1db2d84c671f912021-11-20T05:10:45ZEpithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model2589-004210.1016/j.isci.2021.103369https://doaj.org/article/7d5fcf03a27a4c14bb1db2d84c671f912021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013407https://doaj.org/toc/2589-0042Summary: Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need for Wnts. Here we describe a class of colon cancer that does not depend on mutated core components of the Wnt pathway. Genetically blocking Wnt secretion from epithelial cells of such tumors results in apoptosis, reduced expression of colon cancer markers, followed by enhanced tumor differentiation. In contrast to the normal colonic epithelium, such tumor cells autosecrete Wnts to maintain their uncontrolled proliferative behavior. In humans, we determined certain cases of colon cancers in which the Wnt pathway is hyperactive, but not through mutations in its core components. Our findings illuminate the path in therapy to find further subtypes of Wnt-dependent colon cancer that might be responsive to Wnt secretion inhibitors.Bahar DegirmenciCansu DincerHabibe Cansu DemirelLinda BerkovaAndreas E. MoorAbdullah KahramanGeorge HausmannMichel AguetNurcan TuncbagTomas ValentaKonrad BaslerElsevierarticleMolecular physiologyImmunologyCell biologyCancerOmicsScienceQENiScience, Vol 24, Iss 12, Pp 103369- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Molecular physiology Immunology Cell biology Cancer Omics Science Q
spellingShingle	Molecular physiology Immunology Cell biology Cancer Omics Science Q Bahar Degirmenci Cansu Dincer Habibe Cansu Demirel Linda Berkova Andreas E. Moor Abdullah Kahraman George Hausmann Michel Aguet Nurcan Tuncbag Tomas Valenta Konrad Basler Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
description	Summary: Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need for Wnts. Here we describe a class of colon cancer that does not depend on mutated core components of the Wnt pathway. Genetically blocking Wnt secretion from epithelial cells of such tumors results in apoptosis, reduced expression of colon cancer markers, followed by enhanced tumor differentiation. In contrast to the normal colonic epithelium, such tumor cells autosecrete Wnts to maintain their uncontrolled proliferative behavior. In humans, we determined certain cases of colon cancers in which the Wnt pathway is hyperactive, but not through mutations in its core components. Our findings illuminate the path in therapy to find further subtypes of Wnt-dependent colon cancer that might be responsive to Wnt secretion inhibitors.
format	article
author	Bahar Degirmenci Cansu Dincer Habibe Cansu Demirel Linda Berkova Andreas E. Moor Abdullah Kahraman George Hausmann Michel Aguet Nurcan Tuncbag Tomas Valenta Konrad Basler
author_facet	Bahar Degirmenci Cansu Dincer Habibe Cansu Demirel Linda Berkova Andreas E. Moor Abdullah Kahraman George Hausmann Michel Aguet Nurcan Tuncbag Tomas Valenta Konrad Basler
author_sort	Bahar Degirmenci
title	Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
title_short	Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
title_full	Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
title_fullStr	Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
title_full_unstemmed	Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
title_sort	epithelial wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/7d5fcf03a27a4c14bb1db2d84c671f91
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Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model

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