The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.

Phagocytosis, one of the most powerful immune responses, is a complicated process regulated by many factors. However the regulation of phagocytosis mediated by microRNAs has not been extensively investigated. To address this issue, the regulation of phagocytosis by miR-1 was characterized in this st...

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Autores principales:	Cuilian Liu, Jiajia Wang, Xiaobo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d63f96a663742b1a398b0d5bc48263c
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spelling	oai:doaj.org-article:7d63f96a663742b1a398b0d5bc48263c2021-11-18T08:15:32ZThe involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.1932-620310.1371/journal.pone.0098747https://doaj.org/article/7d63f96a663742b1a398b0d5bc48263c2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24932654/?tool=EBIhttps://doaj.org/toc/1932-6203Phagocytosis, one of the most powerful immune responses, is a complicated process regulated by many factors. However the regulation of phagocytosis mediated by microRNAs has not been extensively investigated. To address this issue, the regulation of phagocytosis by miR-1 was characterized in this study. The results showed that miR-1 played an important role in the phagocytosis regulation in shrimp in vivo. The sequence analysis indicated that miR-1 was highly conserved from invertebrates to mammals, suggesting that miR-1 might share the similar or same functions in phagocytosis of shrimp hemocytes and mammalian macrophages. The data presented that miR-1 was significantly downregulated in cancerous macrophage RAW264.7 cells compared with those in the isolated murine macrophage and in the immortalized macrophage ANA-1. The findings showed that miR-1 had a great effect on the regulation of phagocytosis in cancerous macrophage by the inhibition of clathrin heavy chain 1 (CLTC1) gene. Therefore our study presented a novel miR-1-mediated regulation of phagocytosis both in invertebrate and in vertebrate.Cuilian LiuJiajia WangXiaobo ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98747 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cuilian Liu Jiajia Wang Xiaobo Zhang The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
description	Phagocytosis, one of the most powerful immune responses, is a complicated process regulated by many factors. However the regulation of phagocytosis mediated by microRNAs has not been extensively investigated. To address this issue, the regulation of phagocytosis by miR-1 was characterized in this study. The results showed that miR-1 played an important role in the phagocytosis regulation in shrimp in vivo. The sequence analysis indicated that miR-1 was highly conserved from invertebrates to mammals, suggesting that miR-1 might share the similar or same functions in phagocytosis of shrimp hemocytes and mammalian macrophages. The data presented that miR-1 was significantly downregulated in cancerous macrophage RAW264.7 cells compared with those in the isolated murine macrophage and in the immortalized macrophage ANA-1. The findings showed that miR-1 had a great effect on the regulation of phagocytosis in cancerous macrophage by the inhibition of clathrin heavy chain 1 (CLTC1) gene. Therefore our study presented a novel miR-1-mediated regulation of phagocytosis both in invertebrate and in vertebrate.
format	article
author	Cuilian Liu Jiajia Wang Xiaobo Zhang
author_facet	Cuilian Liu Jiajia Wang Xiaobo Zhang
author_sort	Cuilian Liu
title	The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
title_short	The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
title_full	The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
title_fullStr	The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
title_full_unstemmed	The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.
title_sort	involvement of mir-1-clathrin pathway in the regulation of phagocytosis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7d63f96a663742b1a398b0d5bc48263c
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The involvement of MiR-1-clathrin pathway in the regulation of phagocytosis.

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