Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer

Abstract Background Helicobacter pylori (H. pylori) prevalence is lower in patients with inflammatory bowel disease (IBD) than in those without IBD, suggesting that H. pylori plays a protective role in IBD. It has been reported that IBD may occur due to H. pylori eradication; however, it is unclear...

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Autores principales:	Yuji Fujita, Keiichi Tominaga, Takanao Tanaka, Takeshi Sugaya, Shigemi Yoshihara
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Fecal calprotectin Helicobacter pylori Ulcerative colitis Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/7d67d6cd0dd044e792ed7b58275becb4
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spelling	oai:doaj.org-article:7d67d6cd0dd044e792ed7b58275becb42021-11-14T12:16:52ZUlcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer10.1186/s12876-021-02010-11471-230Xhttps://doaj.org/article/7d67d6cd0dd044e792ed7b58275becb42021-11-01T00:00:00Zhttps://doi.org/10.1186/s12876-021-02010-1https://doaj.org/toc/1471-230XAbstract Background Helicobacter pylori (H. pylori) prevalence is lower in patients with inflammatory bowel disease (IBD) than in those without IBD, suggesting that H. pylori plays a protective role in IBD. It has been reported that IBD may occur due to H. pylori eradication; however, it is unclear whether H. pylori eradication increases the incidence of IBD. Moreover, the effect of H. pylori eradication on IBD activity is unclear. Case presentation An 11-year-old boy diagnosed with ulcerative colitis (UC) was in clinical remission, with treatment involving 5-aminosalicylic acid. Fecal calprotectin (FC) level had decreased to 33.2 mg/kg, indicating mucosal healing. At age 12, he experienced epigastric pain on an empty stomach, which was relieved with dietary intake. His FC level was elevated without UC symptoms, such as diarrhea and bloody stools. He was diagnosed with H. pylori duodenal ulcer. H. pylori eradication (clarithromycin and amoxicillin for 7 days and a proton-pump inhibitor) led to symptom improvement the day after treatment initiation. However, he developed diarrhea and his FC level remained high despite improvement in duodenal ulcer symptoms and endoscopic findings of H. pylori eradication. Colonoscopy results indicated UC relapse. Conclusions H. pylori eradication may worsen UC activity. However, further studies are required as this case report involved only one pediatric patient with increased UC activity after H. pylori eradication.Yuji FujitaKeiichi TominagaTakanao TanakaTakeshi SugayaShigemi YoshiharaBMCarticleFecal calprotectinHelicobacter pyloriUlcerative colitisDiseases of the digestive system. GastroenterologyRC799-869ENBMC Gastroenterology, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fecal calprotectin Helicobacter pylori Ulcerative colitis Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Fecal calprotectin Helicobacter pylori Ulcerative colitis Diseases of the digestive system. Gastroenterology RC799-869 Yuji Fujita Keiichi Tominaga Takanao Tanaka Takeshi Sugaya Shigemi Yoshihara Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
description	Abstract Background Helicobacter pylori (H. pylori) prevalence is lower in patients with inflammatory bowel disease (IBD) than in those without IBD, suggesting that H. pylori plays a protective role in IBD. It has been reported that IBD may occur due to H. pylori eradication; however, it is unclear whether H. pylori eradication increases the incidence of IBD. Moreover, the effect of H. pylori eradication on IBD activity is unclear. Case presentation An 11-year-old boy diagnosed with ulcerative colitis (UC) was in clinical remission, with treatment involving 5-aminosalicylic acid. Fecal calprotectin (FC) level had decreased to 33.2 mg/kg, indicating mucosal healing. At age 12, he experienced epigastric pain on an empty stomach, which was relieved with dietary intake. His FC level was elevated without UC symptoms, such as diarrhea and bloody stools. He was diagnosed with H. pylori duodenal ulcer. H. pylori eradication (clarithromycin and amoxicillin for 7 days and a proton-pump inhibitor) led to symptom improvement the day after treatment initiation. However, he developed diarrhea and his FC level remained high despite improvement in duodenal ulcer symptoms and endoscopic findings of H. pylori eradication. Colonoscopy results indicated UC relapse. Conclusions H. pylori eradication may worsen UC activity. However, further studies are required as this case report involved only one pediatric patient with increased UC activity after H. pylori eradication.
format	article
author	Yuji Fujita Keiichi Tominaga Takanao Tanaka Takeshi Sugaya Shigemi Yoshihara
author_facet	Yuji Fujita Keiichi Tominaga Takanao Tanaka Takeshi Sugaya Shigemi Yoshihara
author_sort	Yuji Fujita
title	Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
title_short	Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
title_full	Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
title_fullStr	Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
title_full_unstemmed	Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
title_sort	ulcerative colitis relapse after helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7d67d6cd0dd044e792ed7b58275becb4
work_keys_str_mv	AT yujifujita ulcerativecolitisrelapseafterhelicobacterpylorieradicationina12yearoldboywithduodenalulcer AT keiichitominaga ulcerativecolitisrelapseafterhelicobacterpylorieradicationina12yearoldboywithduodenalulcer AT takanaotanaka ulcerativecolitisrelapseafterhelicobacterpylorieradicationina12yearoldboywithduodenalulcer AT takeshisugaya ulcerativecolitisrelapseafterhelicobacterpylorieradicationina12yearoldboywithduodenalulcer AT shigemiyoshihara ulcerativecolitisrelapseafterhelicobacterpylorieradicationina12yearoldboywithduodenalulcer
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Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer

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