Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase

Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.

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Autores principales:	F. Kolbe, S. Safarian, Ż. Piórek, S. Welsch, H. Müller, H. Michel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d6a0997e347454394a5f227151e1a4c
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spelling	oai:doaj.org-article:7d6a0997e347454394a5f227151e1a4c2021-11-28T12:34:08ZCryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase10.1038/s41467-021-27174-y2041-1723https://doaj.org/article/7d6a0997e347454394a5f227151e1a4c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27174-yhttps://doaj.org/toc/2041-1723Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.F. KolbeS. SafarianŻ. PiórekS. WelschH. MüllerH. MichelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q F. Kolbe S. Safarian Ż. Piórek S. Welsch H. Müller H. Michel Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
description	Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.
format	article
author	F. Kolbe S. Safarian Ż. Piórek S. Welsch H. Müller H. Michel
author_facet	F. Kolbe S. Safarian Ż. Piórek S. Welsch H. Müller H. Michel
author_sort	F. Kolbe
title	Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
title_short	Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
title_full	Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
title_fullStr	Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
title_full_unstemmed	Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
title_sort	cryo-em structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d6a0997e347454394a5f227151e1a4c
work_keys_str_mv	AT fkolbe cryoemstructuresofintermediatessuggestanalternativecatalyticreactioncycleforcytochromecoxidase AT ssafarian cryoemstructuresofintermediatessuggestanalternativecatalyticreactioncycleforcytochromecoxidase AT zpiorek cryoemstructuresofintermediatessuggestanalternativecatalyticreactioncycleforcytochromecoxidase AT swelsch cryoemstructuresofintermediatessuggestanalternativecatalyticreactioncycleforcytochromecoxidase AT hmuller cryoemstructuresofintermediatessuggestanalternativecatalyticreactioncycleforcytochromecoxidase AT hmichel cryoemstructuresofintermediatessuggestanalternativecatalyticreactioncycleforcytochromecoxidase
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Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase

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