Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches

Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple stu...

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Autores principales:	Changxi Han, Shaojian Lin, Xingyu Lu, Li Xue, Zhe Bao Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pituitary adenoma macrophages tumor microenvironment immune cell therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/7d6ca085cd3b47d8b735b368636f8ac5
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spelling	oai:doaj.org-article:7d6ca085cd3b47d8b735b368636f8ac52021-12-02T11:49:41ZTumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches1664-239210.3389/fendo.2021.785050https://doaj.org/article/7d6ca085cd3b47d8b735b368636f8ac52021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.785050/fullhttps://doaj.org/toc/1664-2392Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma.Changxi HanShaojian LinXingyu LuLi XueZhe Bao WuFrontiers Media S.A.articlepituitary adenomamacrophagestumor microenvironmentimmune celltherapyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pituitary adenoma macrophages tumor microenvironment immune cell therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	pituitary adenoma macrophages tumor microenvironment immune cell therapy Diseases of the endocrine glands. Clinical endocrinology RC648-665 Changxi Han Shaojian Lin Xingyu Lu Li Xue Zhe Bao Wu Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
description	Macrophages are one of the most common infiltrating immune cells and an essential component of tumor microenvironment. Macrophages and the soluble cytokines and chemokines produced play an important role in tumorigenesis, progression, invasion and metastasis in solid tumors. Despite the multiple studies in other solid tumors, there is little known about macrophages in pituitary adenomas. Recently, studies about pituitary adenoma-infiltrated macrophages have been emerging, including the immunohistochemical and immunophenotypic analysis of the pituitary adenomas and further studies into the mechanism of the crosstalk between macrophages and tumor cells in vivo and in vitro. These studies have offered us new insights into the polarization of macrophages and its role in tumorigenesis, progression and invasion of pituitary adenomas. This review describes the advances in the field of pituitary adenoma-infiltrated macrophages and the prospect of targeting macrophages as cancer therapy in pituitary adenoma.
format	article
author	Changxi Han Shaojian Lin Xingyu Lu Li Xue Zhe Bao Wu
author_facet	Changxi Han Shaojian Lin Xingyu Lu Li Xue Zhe Bao Wu
author_sort	Changxi Han
title	Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_short	Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_full	Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_fullStr	Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_full_unstemmed	Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches
title_sort	tumor-associated macrophages: new horizons for pituitary adenoma researches
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7d6ca085cd3b47d8b735b368636f8ac5
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Tumor-Associated Macrophages: New Horizons for Pituitary Adenoma Researches

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