IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.
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| Lenguaje: | EN |
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa0 |
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oai:doaj.org-article:7d6cbfdd10b44261bcdec7f07420ffa02021-12-02T15:39:06ZIL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-210.1038/ncomms146472041-1723https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa02017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14647https://doaj.org/toc/2041-1723IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression.Christoph JandlSue M. LiuPablo F. CañeteJoanna WarrenWilliam E. HughesAlexis VogelzangKylie WebsterMaria E. CraigGulbu UzelAlexander DentPolina StepenskyBärbel KellerKlaus WarnatzJonathan SprentCecile KingNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Christoph Jandl Sue M. Liu Pablo F. Cañete Joanna Warren William E. Hughes Alexis Vogelzang Kylie Webster Maria E. Craig Gulbu Uzel Alexander Dent Polina Stepensky Bärbel Keller Klaus Warnatz Jonathan Sprent Cecile King IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 |
| description |
IL-21 is central to follicular helper T cell function and germinal centre responses. Here the authors show that IL-21 signalling directly inhibits T follicular regulatory cells by limiting Bcl-6-dependent IL-2 receptor expression. |
| format |
article |
| author |
Christoph Jandl Sue M. Liu Pablo F. Cañete Joanna Warren William E. Hughes Alexis Vogelzang Kylie Webster Maria E. Craig Gulbu Uzel Alexander Dent Polina Stepensky Bärbel Keller Klaus Warnatz Jonathan Sprent Cecile King |
| author_facet |
Christoph Jandl Sue M. Liu Pablo F. Cañete Joanna Warren William E. Hughes Alexis Vogelzang Kylie Webster Maria E. Craig Gulbu Uzel Alexander Dent Polina Stepensky Bärbel Keller Klaus Warnatz Jonathan Sprent Cecile King |
| author_sort |
Christoph Jandl |
| title |
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 |
| title_short |
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 |
| title_full |
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 |
| title_fullStr |
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 |
| title_full_unstemmed |
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2 |
| title_sort |
il-21 restricts t follicular regulatory t cell proliferation through bcl-6 mediated inhibition of responsiveness to il-2 |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/7d6cbfdd10b44261bcdec7f07420ffa0 |
| work_keys_str_mv |
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| _version_ |
1718385997154091008 |