Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

The intrinsically disordered protein alpha-synuclein (aSyn) forms polymorphic fibrils. Here the authors provide molecular insights into aSyn fibril polymorphism and present the cryo-EM structures of the two predominant species, a rod and a twister both determined at 3.7 Å resolution.

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Binsen Li, Peng Ge, Kevin A. Murray, Phorum Sheth, Meng Zhang, Gayatri Nair, Michael R. Sawaya, Woo Shik Shin, David R. Boyer, Shulin Ye, David S. Eisenberg, Z. Hong Zhou, Lin Jiang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/7d6d7834f70b4294ba675d175de06cd2
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:7d6d7834f70b4294ba675d175de06cd2
record_format	dspace
spelling	oai:doaj.org-article:7d6d7834f70b4294ba675d175de06cd22021-12-02T16:49:49ZCryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel10.1038/s41467-018-05971-22041-1723https://doaj.org/article/7d6d7834f70b4294ba675d175de06cd22018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05971-2https://doaj.org/toc/2041-1723The intrinsically disordered protein alpha-synuclein (aSyn) forms polymorphic fibrils. Here the authors provide molecular insights into aSyn fibril polymorphism and present the cryo-EM structures of the two predominant species, a rod and a twister both determined at 3.7 Å resolution.Binsen LiPeng GeKevin A. MurrayPhorum ShethMeng ZhangGayatri NairMichael R. SawayaWoo Shik ShinDavid R. BoyerShulin YeDavid S. EisenbergZ. Hong ZhouLin JiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Binsen Li Peng Ge Kevin A. Murray Phorum Sheth Meng Zhang Gayatri Nair Michael R. Sawaya Woo Shik Shin David R. Boyer Shulin Ye David S. Eisenberg Z. Hong Zhou Lin Jiang Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
description	The intrinsically disordered protein alpha-synuclein (aSyn) forms polymorphic fibrils. Here the authors provide molecular insights into aSyn fibril polymorphism and present the cryo-EM structures of the two predominant species, a rod and a twister both determined at 3.7 Å resolution.
format	article
author	Binsen Li Peng Ge Kevin A. Murray Phorum Sheth Meng Zhang Gayatri Nair Michael R. Sawaya Woo Shik Shin David R. Boyer Shulin Ye David S. Eisenberg Z. Hong Zhou Lin Jiang
author_facet	Binsen Li Peng Ge Kevin A. Murray Phorum Sheth Meng Zhang Gayatri Nair Michael R. Sawaya Woo Shik Shin David R. Boyer Shulin Ye David S. Eisenberg Z. Hong Zhou Lin Jiang
author_sort	Binsen Li
title	Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
title_short	Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
title_full	Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
title_fullStr	Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
title_full_unstemmed	Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
title_sort	cryo-em of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7d6d7834f70b4294ba675d175de06cd2
work_keys_str_mv	AT binsenli cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT pengge cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT kevinamurray cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT phorumsheth cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT mengzhang cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT gayatrinair cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT michaelrsawaya cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT wooshikshin cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT davidrboyer cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT shulinye cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT davidseisenberg cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT zhongzhou cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel AT linjiang cryoemoffulllengthasynucleinrevealsfibrilpolymorphswithacommonstructuralkernel
_version_	1718383224142430208

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

Documents similaires