STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA

The goal of present study was to perform a comparative evaluation of cytokine levels in blood of 123 patients with uncomplicated influenza versus a group of cases complicated by subsequent pneumonia. Higher levels of TNFα, IL-10, IL-6, IL-8 and lower levels of IFNγ were found in blood serum of those...

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Autores principales:	L. V. Voloshchuk, E. G. Golovacheva, A. L. Mushkatina, L. V. Osidak, P. V. Zarishnuk, E. G. Rozhkova, T. L. Tumina, A. A. Go
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	influenza pneumonia cytokines correlation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7d7039142e9c4eb28de30b0bd1ff671f
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spelling	oai:doaj.org-article:7d7039142e9c4eb28de30b0bd1ff671f2021-11-18T08:03:43ZSTUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA1563-06252313-741X10.15789/1563-0625-2014-3-265-272https://doaj.org/article/7d7039142e9c4eb28de30b0bd1ff671f2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/692https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe goal of present study was to perform a comparative evaluation of cytokine levels in blood of 123 patients with uncomplicated influenza versus a group of cases complicated by subsequent pneumonia. Higher levels of TNFα, IL-10, IL-6, IL-8 and lower levels of IFNγ were found in blood serum of those patients who developed pneumonia during acute phase of influenza. We have revealed a correlation between the severity and duration of symptoms of both uncomplicated and pneumonia-conplicated flu, and serum concentrations of proinflammatory (TNFα, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-1rа, и IL-10), as well as with indexes of interferon profile (antiIFNα, IFNα и IFNγ) in the patients.L. V. VoloshchukE. G. GolovachevaA. L. MushkatinaL. V. OsidakP. V. ZarishnukE. G. RozhkovaT. L. TuminaA. A. GoSPb RAACIarticleinfluenzapneumoniacytokinescorrelationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 265-272 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza pneumonia cytokines correlation Immunologic diseases. Allergy RC581-607
spellingShingle	influenza pneumonia cytokines correlation Immunologic diseases. Allergy RC581-607 L. V. Voloshchuk E. G. Golovacheva A. L. Mushkatina L. V. Osidak P. V. Zarishnuk E. G. Rozhkova T. L. Tumina A. A. Go STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
description	The goal of present study was to perform a comparative evaluation of cytokine levels in blood of 123 patients with uncomplicated influenza versus a group of cases complicated by subsequent pneumonia. Higher levels of TNFα, IL-10, IL-6, IL-8 and lower levels of IFNγ were found in blood serum of those patients who developed pneumonia during acute phase of influenza. We have revealed a correlation between the severity and duration of symptoms of both uncomplicated and pneumonia-conplicated flu, and serum concentrations of proinflammatory (TNFα, IL-1β, IL-6, IL-8) and anti-inflammatory cytokines (IL-1rа, и IL-10), as well as with indexes of interferon profile (antiIFNα, IFNα и IFNγ) in the patients.
format	article
author	L. V. Voloshchuk E. G. Golovacheva A. L. Mushkatina L. V. Osidak P. V. Zarishnuk E. G. Rozhkova T. L. Tumina A. A. Go
author_facet	L. V. Voloshchuk E. G. Golovacheva A. L. Mushkatina L. V. Osidak P. V. Zarishnuk E. G. Rozhkova T. L. Tumina A. A. Go
author_sort	L. V. Voloshchuk
title	STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
title_short	STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
title_full	STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
title_fullStr	STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
title_full_unstemmed	STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA
title_sort	study of cytokine profile in influenza complicated by pneumonia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7d7039142e9c4eb28de30b0bd1ff671f
work_keys_str_mv	AT lvvoloshchuk studyofcytokineprofileininfluenzacomplicatedbypneumonia AT eggolovacheva studyofcytokineprofileininfluenzacomplicatedbypneumonia AT almushkatina studyofcytokineprofileininfluenzacomplicatedbypneumonia AT lvosidak studyofcytokineprofileininfluenzacomplicatedbypneumonia AT pvzarishnuk studyofcytokineprofileininfluenzacomplicatedbypneumonia AT egrozhkova studyofcytokineprofileininfluenzacomplicatedbypneumonia AT tltumina studyofcytokineprofileininfluenzacomplicatedbypneumonia AT aago studyofcytokineprofileininfluenzacomplicatedbypneumonia
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STUDY OF CYTOKINE PROFILE IN INFLUENZA COMPLICATED BY PNEUMONIA

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