Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia

Abstract Obesity is a well-known risk factor for colorectal neoplasia. Yet, the associations of both metabolic and obesity status with metachronous colorectal neoplasia remain unclear. We conducted a cohort study of 9,331 adults who underwent screening colonoscopy and surveillance colonoscopy. Parti...

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Autores principales:	Tae Jun Kim, Eun Ran Kim, Sung Noh Hong, Young-Ho Kim, Dong Kyung Chang, Jaehwan Ji, Jee Eun Kim, Hye Seung Kim, Kyunga Kim, Hee Jung Son
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d712f70ceee4591bedd27d644f143a7
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spelling	oai:doaj.org-article:7d712f70ceee4591bedd27d644f143a72021-12-02T15:06:27ZMetabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia10.1038/s41598-017-08964-12045-2322https://doaj.org/article/7d712f70ceee4591bedd27d644f143a72017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08964-1https://doaj.org/toc/2045-2322Abstract Obesity is a well-known risk factor for colorectal neoplasia. Yet, the associations of both metabolic and obesity status with metachronous colorectal neoplasia remain unclear. We conducted a cohort study of 9,331 adults who underwent screening colonoscopy and surveillance colonoscopy. Participants were classified as metabolically healthy if they had no metabolic syndrome component. Participants were categorized into four groups according to body mass index and metabolic status: metabolically healthy non-obese (MHNO; n = 2,745), metabolically abnormal non-obese (MANO; n = 3,267), metabolically healthy obese (MHO; n = 707), and metabolically abnormal obese (MAO; n = 2,612). MAO individuals [n = 159 advanced colorectal neoplasia (AN) cases, 6.1%] and MANO individuals (n = 167 AN cases, 5.1%) had a higher incidence of AN compared with MHNO individuals (n = 79 AN cases, 2.9%). In a multivariable model, the risk of metachronous AN was higher in MANO (hazard ratio [HR] 1.43, 95% confidence interval [CI] 1.12–1.84) and MAO (HR 1.52, 95% CI 1.18–1.96) than in MHNO. In contrast, the risk of metachronous AN was not significantly elevated in MHO. In subgroup analyses, with or without adenoma at baseline, MAO was a risk group for metachronous AN, and MHO was not. Our findings suggest that metabolic unhealthiness is a significant predictor for metachronous AN.Tae Jun KimEun Ran KimSung Noh HongYoung-Ho KimDong Kyung ChangJaehwan JiJee Eun KimHye Seung KimKyunga KimHee Jung SonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tae Jun Kim Eun Ran Kim Sung Noh Hong Young-Ho Kim Dong Kyung Chang Jaehwan Ji Jee Eun Kim Hye Seung Kim Kyunga Kim Hee Jung Son Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
description	Abstract Obesity is a well-known risk factor for colorectal neoplasia. Yet, the associations of both metabolic and obesity status with metachronous colorectal neoplasia remain unclear. We conducted a cohort study of 9,331 adults who underwent screening colonoscopy and surveillance colonoscopy. Participants were classified as metabolically healthy if they had no metabolic syndrome component. Participants were categorized into four groups according to body mass index and metabolic status: metabolically healthy non-obese (MHNO; n = 2,745), metabolically abnormal non-obese (MANO; n = 3,267), metabolically healthy obese (MHO; n = 707), and metabolically abnormal obese (MAO; n = 2,612). MAO individuals [n = 159 advanced colorectal neoplasia (AN) cases, 6.1%] and MANO individuals (n = 167 AN cases, 5.1%) had a higher incidence of AN compared with MHNO individuals (n = 79 AN cases, 2.9%). In a multivariable model, the risk of metachronous AN was higher in MANO (hazard ratio [HR] 1.43, 95% confidence interval [CI] 1.12–1.84) and MAO (HR 1.52, 95% CI 1.18–1.96) than in MHNO. In contrast, the risk of metachronous AN was not significantly elevated in MHO. In subgroup analyses, with or without adenoma at baseline, MAO was a risk group for metachronous AN, and MHO was not. Our findings suggest that metabolic unhealthiness is a significant predictor for metachronous AN.
format	article
author	Tae Jun Kim Eun Ran Kim Sung Noh Hong Young-Ho Kim Dong Kyung Chang Jaehwan Ji Jee Eun Kim Hye Seung Kim Kyunga Kim Hee Jung Son
author_facet	Tae Jun Kim Eun Ran Kim Sung Noh Hong Young-Ho Kim Dong Kyung Chang Jaehwan Ji Jee Eun Kim Hye Seung Kim Kyunga Kim Hee Jung Son
author_sort	Tae Jun Kim
title	Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
title_short	Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
title_full	Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
title_fullStr	Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
title_full_unstemmed	Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
title_sort	metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7d712f70ceee4591bedd27d644f143a7
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Metabolic unhealthiness is an important predictor for the development of advanced colorectal neoplasia

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