Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder
Accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (H2S), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study inve...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:7d7181367e2849dc821c8879106edddd2021-11-11T06:40:30ZDecreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder1664-064010.3389/fpsyt.2021.765664https://doaj.org/article/7d7181367e2849dc821c8879106edddd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.765664/fullhttps://doaj.org/toc/1664-0640Accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (H2S), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study investigated the relationship between plasma H2S levels and the depressive symptoms in patients with depression. Forty-seven depressed patients and 51 healthy individuals were recruited in this study. The 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate depressive symptoms for all subjects and the reversed-phase high-performance liquid chromatography (RP-HPLC) was used to measure plasmaH2S levels. We found that plasma H2S levels were significantly lower in patients with depression relative to healthy individuals (P < 0.001). Compared with healthy controls (1.02 ± 0.34 μmol/L), the plasma H2S level significantly decreased in patients with mild depression (0.84 ± 0.28 μmol/L), with moderate depression (0.62 ± 0.21μmol/L), and with severe depression (0.38 ± 0.18 μmol/L). Correlation analysis revealed that plasma H2S levels were significantly negatively correlated with the HAMD-17 scores in patients (r = −0.484, P = 0.001). Multivariate linear regression analysis showed that plasma H2S was an independent contributor to the HAMD-17 score in patients (B = −0.360, t = −2.550, P = 0.015). Collectively, these results suggest that decreased H2S is involved in the pathophysiology of depression, and plasma H2S might be a potential indicator for depression severity.Yuan-Jian YangYuan-Jian YangYuan-Jian YangChun-Nuan ChenJin-Qiong ZhanJin-Qiong ZhanQiao-Sheng LiuQiao-Sheng LiuYun LiuShu-Zhen JiangBo WeiBo WeiBo WeiFrontiers Media S.A.articledepressionhydrogen sulfide (H2S)plasmaseveritycorrelationPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021) |
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depression hydrogen sulfide (H2S) plasma severity correlation Psychiatry RC435-571 |
| spellingShingle |
depression hydrogen sulfide (H2S) plasma severity correlation Psychiatry RC435-571 Yuan-Jian Yang Yuan-Jian Yang Yuan-Jian Yang Chun-Nuan Chen Jin-Qiong Zhan Jin-Qiong Zhan Qiao-Sheng Liu Qiao-Sheng Liu Yun Liu Shu-Zhen Jiang Bo Wei Bo Wei Bo Wei Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| description |
Accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (H2S), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study investigated the relationship between plasma H2S levels and the depressive symptoms in patients with depression. Forty-seven depressed patients and 51 healthy individuals were recruited in this study. The 17-item Hamilton Depression Rating Scale (HAMD-17) was used to evaluate depressive symptoms for all subjects and the reversed-phase high-performance liquid chromatography (RP-HPLC) was used to measure plasmaH2S levels. We found that plasma H2S levels were significantly lower in patients with depression relative to healthy individuals (P < 0.001). Compared with healthy controls (1.02 ± 0.34 μmol/L), the plasma H2S level significantly decreased in patients with mild depression (0.84 ± 0.28 μmol/L), with moderate depression (0.62 ± 0.21μmol/L), and with severe depression (0.38 ± 0.18 μmol/L). Correlation analysis revealed that plasma H2S levels were significantly negatively correlated with the HAMD-17 scores in patients (r = −0.484, P = 0.001). Multivariate linear regression analysis showed that plasma H2S was an independent contributor to the HAMD-17 score in patients (B = −0.360, t = −2.550, P = 0.015). Collectively, these results suggest that decreased H2S is involved in the pathophysiology of depression, and plasma H2S might be a potential indicator for depression severity. |
| format |
article |
| author |
Yuan-Jian Yang Yuan-Jian Yang Yuan-Jian Yang Chun-Nuan Chen Jin-Qiong Zhan Jin-Qiong Zhan Qiao-Sheng Liu Qiao-Sheng Liu Yun Liu Shu-Zhen Jiang Bo Wei Bo Wei Bo Wei |
| author_facet |
Yuan-Jian Yang Yuan-Jian Yang Yuan-Jian Yang Chun-Nuan Chen Jin-Qiong Zhan Jin-Qiong Zhan Qiao-Sheng Liu Qiao-Sheng Liu Yun Liu Shu-Zhen Jiang Bo Wei Bo Wei Bo Wei |
| author_sort |
Yuan-Jian Yang |
| title |
Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_short |
Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_full |
Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_fullStr |
Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_full_unstemmed |
Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder |
| title_sort |
decreased plasma hydrogen sulfide level is associated with the severity of depression in patients with depressive disorder |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/7d7181367e2849dc821c8879106edddd |
| work_keys_str_mv |
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