Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

Brunnberg et al. establish a protocol that enables them to optically control translocation of the transporter associated with antigen processing (TAP), which plays a role in delivering proteasomal degradation products into the ER lumen. Their versatile approach provides insights into TAP function in...

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Autores principales:	Jamina Brunnberg, Valentina Herbring, Esteban Günther Castillo, Heike Krüger, Ralph Wieneke, Robert Tampé
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7d742d0a34ce4d60b7958af938b31d53
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spelling	oai:doaj.org-article:7d742d0a34ce4d60b7958af938b31d532021-12-02T13:27:04ZLight control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking10.1038/s42003-021-01890-z2399-3642https://doaj.org/article/7d742d0a34ce4d60b7958af938b31d532021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01890-zhttps://doaj.org/toc/2399-3642Brunnberg et al. establish a protocol that enables them to optically control translocation of the transporter associated with antigen processing (TAP), which plays a role in delivering proteasomal degradation products into the ER lumen. Their versatile approach provides insights into TAP function in the context of peptide-loading complex and stable peptide-MHC I complex trafficking in living cells, but has the potential to be applied to the investigation of other pathways.Jamina BrunnbergValentina HerbringEsteban Günther CastilloHeike KrügerRalph WienekeRobert TampéNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jamina Brunnberg Valentina Herbring Esteban Günther Castillo Heike Krüger Ralph Wieneke Robert Tampé Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
description	Brunnberg et al. establish a protocol that enables them to optically control translocation of the transporter associated with antigen processing (TAP), which plays a role in delivering proteasomal degradation products into the ER lumen. Their versatile approach provides insights into TAP function in the context of peptide-loading complex and stable peptide-MHC I complex trafficking in living cells, but has the potential to be applied to the investigation of other pathways.
format	article
author	Jamina Brunnberg Valentina Herbring Esteban Günther Castillo Heike Krüger Ralph Wieneke Robert Tampé
author_facet	Jamina Brunnberg Valentina Herbring Esteban Günther Castillo Heike Krüger Ralph Wieneke Robert Tampé
author_sort	Jamina Brunnberg
title	Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
title_short	Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
title_full	Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
title_fullStr	Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
title_full_unstemmed	Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking
title_sort	light control of the peptide-loading complex synchronizes antigen translocation and mhc i trafficking
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d742d0a34ce4d60b7958af938b31d53
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Light control of the peptide-loading complex synchronizes antigen translocation and MHC I trafficking

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