A single transcript for the prognosis of disease severity in COVID-19 patients

Abstract With many countries strapped for medical resources due to the COVID-19 pandemic, it is highly desirable to allocate the precious resources to those who need them the most. Several markers have been found to be associated with the disease severity in COVID-19 patients. However, the establish...

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Autor principal:	Hongxing Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d7e331228a343719ae8c908528a62a0
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spelling	oai:doaj.org-article:7d7e331228a343719ae8c908528a62a02021-12-02T17:47:18ZA single transcript for the prognosis of disease severity in COVID-19 patients10.1038/s41598-021-91754-72045-2322https://doaj.org/article/7d7e331228a343719ae8c908528a62a02021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91754-7https://doaj.org/toc/2045-2322Abstract With many countries strapped for medical resources due to the COVID-19 pandemic, it is highly desirable to allocate the precious resources to those who need them the most. Several markers have been found to be associated with the disease severity in COVID-19 patients. However, the established markers only display modest prognostic power individually and better markers are urgently needed. The aim of this study is to investigate the potential of S100A12, a prominent marker gene for bacterial infection, in the prognosis of disease severity in COVID-19 patients. To ensure the robustness of the association, a total of 1695 samples from 14 independent transcriptome datasets on sepsis, influenza infection and COVID-19 infection were examined. First, it was demonstrated that S100A12 was a marker for sepsis and severity of sepsis. Then, S100A12 was found to be a marker for severe influenza infection, and there was an upward trend of S100A12 expression as the severity level of influenza infection increased. As for COVID-19 infection, it was found that S100A12 expression was elevated in patients with severe and critical COVID-19 infection. More importantly, S100A12 expression at hospital admission was robustly correlated with future quantitative indexes of disease severity and outcome in COVID-19 patients, superior to established prognostic markers including CRP, PCT, d-dimer, ferritin, LDH and fibrinogen. Thus, S100A12 is a valuable novel prognostic marker for COVID-19 severity and deserves more attention.Hongxing LeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hongxing Lei A single transcript for the prognosis of disease severity in COVID-19 patients
description	Abstract With many countries strapped for medical resources due to the COVID-19 pandemic, it is highly desirable to allocate the precious resources to those who need them the most. Several markers have been found to be associated with the disease severity in COVID-19 patients. However, the established markers only display modest prognostic power individually and better markers are urgently needed. The aim of this study is to investigate the potential of S100A12, a prominent marker gene for bacterial infection, in the prognosis of disease severity in COVID-19 patients. To ensure the robustness of the association, a total of 1695 samples from 14 independent transcriptome datasets on sepsis, influenza infection and COVID-19 infection were examined. First, it was demonstrated that S100A12 was a marker for sepsis and severity of sepsis. Then, S100A12 was found to be a marker for severe influenza infection, and there was an upward trend of S100A12 expression as the severity level of influenza infection increased. As for COVID-19 infection, it was found that S100A12 expression was elevated in patients with severe and critical COVID-19 infection. More importantly, S100A12 expression at hospital admission was robustly correlated with future quantitative indexes of disease severity and outcome in COVID-19 patients, superior to established prognostic markers including CRP, PCT, d-dimer, ferritin, LDH and fibrinogen. Thus, S100A12 is a valuable novel prognostic marker for COVID-19 severity and deserves more attention.
format	article
author	Hongxing Lei
author_facet	Hongxing Lei
author_sort	Hongxing Lei
title	A single transcript for the prognosis of disease severity in COVID-19 patients
title_short	A single transcript for the prognosis of disease severity in COVID-19 patients
title_full	A single transcript for the prognosis of disease severity in COVID-19 patients
title_fullStr	A single transcript for the prognosis of disease severity in COVID-19 patients
title_full_unstemmed	A single transcript for the prognosis of disease severity in COVID-19 patients
title_sort	single transcript for the prognosis of disease severity in covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7d7e331228a343719ae8c908528a62a0
work_keys_str_mv	AT hongxinglei asingletranscriptfortheprognosisofdiseaseseverityincovid19patients AT hongxinglei singletranscriptfortheprognosisofdiseaseseverityincovid19patients
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A single transcript for the prognosis of disease severity in COVID-19 patients

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