Variance and covariance of actual relationships between relatives at one locus.

The relationship between pairs of individuals is an important topic in many areas of population and quantitative genetics. It is usually measured as the proportion of the genome identical by descent shared by the pair and it can be inferred from pedigree information. But there is a variance in actua...

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Autores principales:	Luis Alberto Garcia-Cortes, Andres Legarra, Claude Chevalet, Miguel Angel Toro
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d83454e345e43c59f02dd3daf2b8527
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spelling	oai:doaj.org-article:7d83454e345e43c59f02dd3daf2b85272021-11-18T07:56:21ZVariance and covariance of actual relationships between relatives at one locus.1932-620310.1371/journal.pone.0057003https://doaj.org/article/7d83454e345e43c59f02dd3daf2b85272013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23451134/?tool=EBIhttps://doaj.org/toc/1932-6203The relationship between pairs of individuals is an important topic in many areas of population and quantitative genetics. It is usually measured as the proportion of the genome identical by descent shared by the pair and it can be inferred from pedigree information. But there is a variance in actual relationships as a consequence of mendelian sampling, whose general formula has not been developed. The goal of this work is to develop this general formula for the one-locus situation,. We provide simple expressions for the variances and covariances of all actual relationships in an arbitrary complex pedigree. The proposed method relies on the use of the nine identity coefficients and the generalized relationship coefficients; formulas have been checked by computer simulation. Finally two examples for a short pedigree of dogs and a long pedigree of sheep are given.Luis Alberto Garcia-CortesAndres LegarraClaude ChevaletMiguel Angel ToroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57003 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luis Alberto Garcia-Cortes Andres Legarra Claude Chevalet Miguel Angel Toro Variance and covariance of actual relationships between relatives at one locus.
description	The relationship between pairs of individuals is an important topic in many areas of population and quantitative genetics. It is usually measured as the proportion of the genome identical by descent shared by the pair and it can be inferred from pedigree information. But there is a variance in actual relationships as a consequence of mendelian sampling, whose general formula has not been developed. The goal of this work is to develop this general formula for the one-locus situation,. We provide simple expressions for the variances and covariances of all actual relationships in an arbitrary complex pedigree. The proposed method relies on the use of the nine identity coefficients and the generalized relationship coefficients; formulas have been checked by computer simulation. Finally two examples for a short pedigree of dogs and a long pedigree of sheep are given.
format	article
author	Luis Alberto Garcia-Cortes Andres Legarra Claude Chevalet Miguel Angel Toro
author_facet	Luis Alberto Garcia-Cortes Andres Legarra Claude Chevalet Miguel Angel Toro
author_sort	Luis Alberto Garcia-Cortes
title	Variance and covariance of actual relationships between relatives at one locus.
title_short	Variance and covariance of actual relationships between relatives at one locus.
title_full	Variance and covariance of actual relationships between relatives at one locus.
title_fullStr	Variance and covariance of actual relationships between relatives at one locus.
title_full_unstemmed	Variance and covariance of actual relationships between relatives at one locus.
title_sort	variance and covariance of actual relationships between relatives at one locus.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7d83454e345e43c59f02dd3daf2b8527
work_keys_str_mv	AT luisalbertogarciacortes varianceandcovarianceofactualrelationshipsbetweenrelativesatonelocus AT andreslegarra varianceandcovarianceofactualrelationshipsbetweenrelativesatonelocus AT claudechevalet varianceandcovarianceofactualrelationshipsbetweenrelativesatonelocus AT miguelangeltoro varianceandcovarianceofactualrelationshipsbetweenrelativesatonelocus
_version_	1718422740795392000

Variance and covariance of actual relationships between relatives at one locus.

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