Genetic variation and RNA structure regulate microRNA biogenesis

A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.

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Detalles Bibliográficos
Autores principales: Noemi Fernandez, Ross A. Cordiner, Robert S. Young, Nele Hug, Sara Macias, Javier F. Cáceres
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7d860a2bd39d43cd92eaf8718314b299
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Descripción
Sumario:A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.