Genetic variation and RNA structure regulate microRNA biogenesis

A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.

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Autores principales:	Noemi Fernandez, Ross A. Cordiner, Robert S. Young, Nele Hug, Sara Macias, Javier F. Cáceres
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d860a2bd39d43cd92eaf8718314b299
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spelling	oai:doaj.org-article:7d860a2bd39d43cd92eaf8718314b2992021-12-02T14:40:23ZGenetic variation and RNA structure regulate microRNA biogenesis10.1038/ncomms151142041-1723https://doaj.org/article/7d860a2bd39d43cd92eaf8718314b2992017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15114https://doaj.org/toc/2041-1723A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.Noemi FernandezRoss A. CordinerRobert S. YoungNele HugSara MaciasJavier F. CáceresNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Noemi Fernandez Ross A. Cordiner Robert S. Young Nele Hug Sara Macias Javier F. Cáceres Genetic variation and RNA structure regulate microRNA biogenesis
description	A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased Drosha-mediated processing.
format	article
author	Noemi Fernandez Ross A. Cordiner Robert S. Young Nele Hug Sara Macias Javier F. Cáceres
author_facet	Noemi Fernandez Ross A. Cordiner Robert S. Young Nele Hug Sara Macias Javier F. Cáceres
author_sort	Noemi Fernandez
title	Genetic variation and RNA structure regulate microRNA biogenesis
title_short	Genetic variation and RNA structure regulate microRNA biogenesis
title_full	Genetic variation and RNA structure regulate microRNA biogenesis
title_fullStr	Genetic variation and RNA structure regulate microRNA biogenesis
title_full_unstemmed	Genetic variation and RNA structure regulate microRNA biogenesis
title_sort	genetic variation and rna structure regulate microrna biogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7d860a2bd39d43cd92eaf8718314b299
work_keys_str_mv	AT noemifernandez geneticvariationandrnastructureregulatemicrornabiogenesis AT rossacordiner geneticvariationandrnastructureregulatemicrornabiogenesis AT robertsyoung geneticvariationandrnastructureregulatemicrornabiogenesis AT nelehug geneticvariationandrnastructureregulatemicrornabiogenesis AT saramacias geneticvariationandrnastructureregulatemicrornabiogenesis AT javierfcaceres geneticvariationandrnastructureregulatemicrornabiogenesis
_version_	1718390304782942208

Genetic variation and RNA structure regulate microRNA biogenesis

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