The Membrane-Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes

The Membrane-Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes

ABSTRACT Glycoprotein B (gB), gD, and gH/gL constitute the fusion machinery of herpes simplex virus (HSV). Prior studies indicated that fusion occurs in a stepwise fashion whereby the gD/receptor complex activates the entire process, while gH/gL regulates the fusion reaction carried out by gB. Trime...

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Autores principales: Spencer S. Shelly, Tina M. Cairns, J. Charles Whitbeck, Huan Lou, Claude Krummenacher, Gary H. Cohen, Roselyn J. Eisenberg
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2012
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/7d861036838f4b77a65ff46f03295d0d
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