Phosphatidylserine exposure is required for ADAM17 sheddase function

ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its s...

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Autores principales:	Anselm Sommer, Felix Kordowski, Joscha Büch, Thorsten Maretzky, Astrid Evers, Jörg Andrä, Stefan Düsterhöft, Matthias Michalek, Inken Lorenzen, Prasath Somasundaram, Andreas Tholey, Frank D. Sönnichsen, Karl Kunzelmann, Lena Heinbockel, Christian Nehls, Thomas Gutsmann, Joachim Grötzinger, Sucharit Bhakdi, Karina Reiss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d870aa38fd548259ffdc80c22adca2f
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spelling	oai:doaj.org-article:7d870aa38fd548259ffdc80c22adca2f2021-12-02T14:39:14ZPhosphatidylserine exposure is required for ADAM17 sheddase function10.1038/ncomms115232041-1723https://doaj.org/article/7d870aa38fd548259ffdc80c22adca2f2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11523https://doaj.org/toc/2041-1723ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates.Anselm SommerFelix KordowskiJoscha BüchThorsten MaretzkyAstrid EversJörg AndräStefan DüsterhöftMatthias MichalekInken LorenzenPrasath SomasundaramAndreas TholeyFrank D. SönnichsenKarl KunzelmannLena HeinbockelChristian NehlsThomas GutsmannJoachim GrötzingerSucharit BhakdiKarina ReissNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anselm Sommer Felix Kordowski Joscha Büch Thorsten Maretzky Astrid Evers Jörg Andrä Stefan Düsterhöft Matthias Michalek Inken Lorenzen Prasath Somasundaram Andreas Tholey Frank D. Sönnichsen Karl Kunzelmann Lena Heinbockel Christian Nehls Thomas Gutsmann Joachim Grötzinger Sucharit Bhakdi Karina Reiss Phosphatidylserine exposure is required for ADAM17 sheddase function
description	ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase activity, possibly by directing the protease to its substrates.
format	article
author	Anselm Sommer Felix Kordowski Joscha Büch Thorsten Maretzky Astrid Evers Jörg Andrä Stefan Düsterhöft Matthias Michalek Inken Lorenzen Prasath Somasundaram Andreas Tholey Frank D. Sönnichsen Karl Kunzelmann Lena Heinbockel Christian Nehls Thomas Gutsmann Joachim Grötzinger Sucharit Bhakdi Karina Reiss
author_facet	Anselm Sommer Felix Kordowski Joscha Büch Thorsten Maretzky Astrid Evers Jörg Andrä Stefan Düsterhöft Matthias Michalek Inken Lorenzen Prasath Somasundaram Andreas Tholey Frank D. Sönnichsen Karl Kunzelmann Lena Heinbockel Christian Nehls Thomas Gutsmann Joachim Grötzinger Sucharit Bhakdi Karina Reiss
author_sort	Anselm Sommer
title	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_short	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_full	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_fullStr	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_full_unstemmed	Phosphatidylserine exposure is required for ADAM17 sheddase function
title_sort	phosphatidylserine exposure is required for adam17 sheddase function
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7d870aa38fd548259ffdc80c22adca2f
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Phosphatidylserine exposure is required for ADAM17 sheddase function

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