Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population

Nurgul Sikhayeva,1,2 Yerkebulan Talzhanov,1 Aisha Iskakova,1 Jarkyn Dzharmukhanov,1 Raushan Nugmanova,1 Elena Zholdybaeva,1 Erlan Ramanculov1–3 1National Scientific Laboratory of Biotechnology, National Center for Biotechnology, Astana, Kazakhstan; 2Faculty of Natural Sciences, L.N. Gumil...

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Autores principales:	Sikhayeva N, Talzhanov Y, Iskakova A, Dzharmukhanov J, Nugmanova R, Zholdybaeva E, Ramanculov E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Single nucleotide polymorphism Kazakh population Type 2 diabetes OpenArray Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7d8873cac59e4622892d3713c4d8af5f
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spelling	oai:doaj.org-article:7d8873cac59e4622892d3713c4d8af5f2021-12-02T05:36:15ZType 2 diabetes mellitus: distribution of genetic markers in Kazakh population1178-1998https://doaj.org/article/7d8873cac59e4622892d3713c4d8af5f2018-03-01T00:00:00Zhttps://www.dovepress.com/type-2-diabetes-mellitus-distribution-of-genetic-markers-in-kazakh-pop-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nurgul Sikhayeva,1,2 Yerkebulan Talzhanov,1 Aisha Iskakova,1 Jarkyn Dzharmukhanov,1 Raushan Nugmanova,1 Elena Zholdybaeva,1 Erlan Ramanculov1–3 1National Scientific Laboratory of Biotechnology, National Center for Biotechnology, Astana, Kazakhstan; 2Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan; 3School of Science and Technology, Nazarbayev University, Astana, Kazakhstan Background: Ethnic differences exist in the frequencies of genetic variations that contribute to the risk of common disease. This study aimed to analyse the distribution of several genes, previously associated with susceptibility to type 2 diabetes and obesity-related phenotypes, in a Kazakh population.Methods: A total of 966 individuals belonging to the Kazakh ethnicity were recruited from an outpatient clinic. We genotyped 41 common single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes in other ethnic groups and 31 of these were in Hardy–Weinberg equilibrium. The obtained allele frequencies were further compared to publicly available data from other ethnic populations. Allele frequencies for other (compared) populations were pooled from the haplotype map (HapMap) database. Principal component analysis (PCA), cluster analysis, and multidimensional scaling (MDS) were used for the analysis of genetic relationship between the populations.Results: Comparative analysis of allele frequencies of the studied SNPs showed significant differentiation among the studied populations. The Kazakh population was grouped with Asian populations according to the cluster analysis and with the Caucasian populations according to PCA. According to MDS, results of the current study show that the Kazakh population holds an intermediate position between Caucasian and Asian populations.Conclusion: A high percentage of population differentiation was observed between Kazakh and world populations. The Kazakh population was clustered with Caucasian populations, and this result may indicate a significant Caucasian component in the Kazakh gene pool. Keywords: single-nucleotide polymorphism, Kazakh population, type 2 diabetes, OpenArraySikhayeva NTalzhanov YIskakova ADzharmukhanov JNugmanova RZholdybaeva ERamanculov EDove Medical PressarticleSingle nucleotide polymorphismKazakh populationType 2 diabetesOpenArrayGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 377-388 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Single nucleotide polymorphism Kazakh population Type 2 diabetes OpenArray Geriatrics RC952-954.6
spellingShingle	Single nucleotide polymorphism Kazakh population Type 2 diabetes OpenArray Geriatrics RC952-954.6 Sikhayeva N Talzhanov Y Iskakova A Dzharmukhanov J Nugmanova R Zholdybaeva E Ramanculov E Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population
description	Nurgul Sikhayeva,1,2 Yerkebulan Talzhanov,1 Aisha Iskakova,1 Jarkyn Dzharmukhanov,1 Raushan Nugmanova,1 Elena Zholdybaeva,1 Erlan Ramanculov1–3 1National Scientific Laboratory of Biotechnology, National Center for Biotechnology, Astana, Kazakhstan; 2Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana, Kazakhstan; 3School of Science and Technology, Nazarbayev University, Astana, Kazakhstan Background: Ethnic differences exist in the frequencies of genetic variations that contribute to the risk of common disease. This study aimed to analyse the distribution of several genes, previously associated with susceptibility to type 2 diabetes and obesity-related phenotypes, in a Kazakh population.Methods: A total of 966 individuals belonging to the Kazakh ethnicity were recruited from an outpatient clinic. We genotyped 41 common single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes in other ethnic groups and 31 of these were in Hardy–Weinberg equilibrium. The obtained allele frequencies were further compared to publicly available data from other ethnic populations. Allele frequencies for other (compared) populations were pooled from the haplotype map (HapMap) database. Principal component analysis (PCA), cluster analysis, and multidimensional scaling (MDS) were used for the analysis of genetic relationship between the populations.Results: Comparative analysis of allele frequencies of the studied SNPs showed significant differentiation among the studied populations. The Kazakh population was grouped with Asian populations according to the cluster analysis and with the Caucasian populations according to PCA. According to MDS, results of the current study show that the Kazakh population holds an intermediate position between Caucasian and Asian populations.Conclusion: A high percentage of population differentiation was observed between Kazakh and world populations. The Kazakh population was clustered with Caucasian populations, and this result may indicate a significant Caucasian component in the Kazakh gene pool. Keywords: single-nucleotide polymorphism, Kazakh population, type 2 diabetes, OpenArray
format	article
author	Sikhayeva N Talzhanov Y Iskakova A Dzharmukhanov J Nugmanova R Zholdybaeva E Ramanculov E
author_facet	Sikhayeva N Talzhanov Y Iskakova A Dzharmukhanov J Nugmanova R Zholdybaeva E Ramanculov E
author_sort	Sikhayeva N
title	Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population
title_short	Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population
title_full	Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population
title_fullStr	Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population
title_full_unstemmed	Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population
title_sort	type 2 diabetes mellitus: distribution of genetic markers in kazakh population
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7d8873cac59e4622892d3713c4d8af5f
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Type 2 diabetes mellitus: distribution of genetic markers in Kazakh population

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