Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.

Aberrant emotional salience attribution has been reported to be an important clinical feature in patients with schizophrenia. Real life stimuli that incorporate both positive and negative emotional traits lead to affective asymmetry such as negativity bias and positivity offset. In this study, we in...

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Autores principales:	Seon-Koo Lee, Ji Won Chun, Jung Suk Lee, Hae-Jeong Park, Young-Chul Jung, Jeong-Ho Seok, Jae-Jin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d8a4cdcf96f4f8c99474a82a9072f46
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spelling	oai:doaj.org-article:7d8a4cdcf96f4f8c99474a82a9072f462021-11-18T08:28:36ZAbnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.1932-620310.1371/journal.pone.0090792https://doaj.org/article/7d8a4cdcf96f4f8c99474a82a9072f462014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24619004/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Aberrant emotional salience attribution has been reported to be an important clinical feature in patients with schizophrenia. Real life stimuli that incorporate both positive and negative emotional traits lead to affective asymmetry such as negativity bias and positivity offset. In this study, we investigated the neural correlates of emotional salience attribution in patients with schizophrenia when affective asymmetry was processed. Fifteen patients with schizophrenia and 14 healthy controls were scanned using functional magnetic resonance imaging (fMRI) while performing an emotion judgment task in which two pictures were juxtaposed. The task consisted of responding to affective asymmetry condition (ambivalent and neutral) and affective symmetry conditions (positive and negative), and group comparisons were performed for each condition. Significantly higher activity in the medial prefrontal cortex and inferior frontal gyrus was observed for the ambivalent condition than for the other conditions in controls, but not in patients. Compared with controls, patients showed decreased activities in the dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, insula, and putamen for the ambivalent condition, but no changes were observed for the neutral condition. Multiple prefrontal hypoactivities during salience attribution of negativity bias in schizophrenia may underlie deficits in the integrative processing of emotional information. Regional abnormalities in the salience network may be the basis of defective emotional salience attribution in schizophrenia, which is likely involved in symptom formation and social dysfunction.Seon-Koo LeeJi Won ChunJung Suk LeeHae-Jeong ParkYoung-Chul JungJeong-Ho SeokJae-Jin KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90792 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seon-Koo Lee Ji Won Chun Jung Suk Lee Hae-Jeong Park Young-Chul Jung Jeong-Ho Seok Jae-Jin Kim Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
description	Aberrant emotional salience attribution has been reported to be an important clinical feature in patients with schizophrenia. Real life stimuli that incorporate both positive and negative emotional traits lead to affective asymmetry such as negativity bias and positivity offset. In this study, we investigated the neural correlates of emotional salience attribution in patients with schizophrenia when affective asymmetry was processed. Fifteen patients with schizophrenia and 14 healthy controls were scanned using functional magnetic resonance imaging (fMRI) while performing an emotion judgment task in which two pictures were juxtaposed. The task consisted of responding to affective asymmetry condition (ambivalent and neutral) and affective symmetry conditions (positive and negative), and group comparisons were performed for each condition. Significantly higher activity in the medial prefrontal cortex and inferior frontal gyrus was observed for the ambivalent condition than for the other conditions in controls, but not in patients. Compared with controls, patients showed decreased activities in the dorsolateral prefrontal cortex, dorsal anterior cingulate cortex, insula, and putamen for the ambivalent condition, but no changes were observed for the neutral condition. Multiple prefrontal hypoactivities during salience attribution of negativity bias in schizophrenia may underlie deficits in the integrative processing of emotional information. Regional abnormalities in the salience network may be the basis of defective emotional salience attribution in schizophrenia, which is likely involved in symptom formation and social dysfunction.
format	article
author	Seon-Koo Lee Ji Won Chun Jung Suk Lee Hae-Jeong Park Young-Chul Jung Jeong-Ho Seok Jae-Jin Kim
author_facet	Seon-Koo Lee Ji Won Chun Jung Suk Lee Hae-Jeong Park Young-Chul Jung Jeong-Ho Seok Jae-Jin Kim
author_sort	Seon-Koo Lee
title	Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
title_short	Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
title_full	Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
title_fullStr	Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
title_full_unstemmed	Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
title_sort	abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7d8a4cdcf96f4f8c99474a82a9072f46
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Abnormal neural processing during emotional salience attribution of affective asymmetry in patients with schizophrenia.

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