Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.

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Autores principales:	Susan E. Tsutakawa, Mark J. Thompson, Andrew S. Arvai, Alexander J. Neil, Steven J. Shaw, Sana I. Algasaier, Jane C. Kim, L. David Finger, Emma Jardine, Victoria J.B. Gotham, Altaf H. Sarker, Mai Z. Her, Fahad Rashid, Samir M. Hamdan, Sergei M. Mirkin, Jane A. Grasby, John A. Tainer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260
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spelling	oai:doaj.org-article:7d8f8666ae664b27be8155fb17c1e2602021-12-02T14:42:10ZPhosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability10.1038/ncomms158552041-1723https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e2602017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15855https://doaj.org/toc/2041-1723Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.Susan E. TsutakawaMark J. ThompsonAndrew S. ArvaiAlexander J. NeilSteven J. ShawSana I. AlgasaierJane C. KimL. David FingerEmma JardineVictoria J.B. GothamAltaf H. SarkerMai Z. HerFahad RashidSamir M. HamdanSergei M. MirkinJane A. GrasbyJohn A. TainerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Susan E. Tsutakawa Mark J. Thompson Andrew S. Arvai Alexander J. Neil Steven J. Shaw Sana I. Algasaier Jane C. Kim L. David Finger Emma Jardine Victoria J.B. Gotham Altaf H. Sarker Mai Z. Her Fahad Rashid Samir M. Hamdan Sergei M. Mirkin Jane A. Grasby John A. Tainer Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
description	Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a process termed ‘phosphate steering’.
format	article
author	Susan E. Tsutakawa Mark J. Thompson Andrew S. Arvai Alexander J. Neil Steven J. Shaw Sana I. Algasaier Jane C. Kim L. David Finger Emma Jardine Victoria J.B. Gotham Altaf H. Sarker Mai Z. Her Fahad Rashid Samir M. Hamdan Sergei M. Mirkin Jane A. Grasby John A. Tainer
author_facet	Susan E. Tsutakawa Mark J. Thompson Andrew S. Arvai Alexander J. Neil Steven J. Shaw Sana I. Algasaier Jane C. Kim L. David Finger Emma Jardine Victoria J.B. Gotham Altaf H. Sarker Mai Z. Her Fahad Rashid Samir M. Hamdan Sergei M. Mirkin Jane A. Grasby John A. Tainer
author_sort	Susan E. Tsutakawa
title	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
title_short	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
title_full	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
title_fullStr	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
title_full_unstemmed	Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
title_sort	phosphate steering by flap endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260
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Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

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