Carbamylation of elastic fibers is a molecular substratum of aortic stiffness

Carbamylation of elastic fibers is a molecular substratum of aortic stiffness

Abstract Because of their long lifespan, matrix proteins of the vascular wall, such as elastin, are subjected to molecular aging characterized by non-enzymatic post-translational modifications, like carbamylation which results from the binding of cyanate (mainly derived from the dissociation of urea...

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Autores principales: Manon Doué, Anaïs Okwieka, Alexandre Berquand, Laëtitia Gorisse, Pascal Maurice, Frédéric Velard, Christine Terryn, Michaël Molinari, Laurent Duca, Christine Piétrement, Philippe Gillery, Stéphane Jaisson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/7d9112e629014374850de6a0f738d8c7
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