Matriptase-2 deficiency protects from obesity by modulating iron homeostasis

Iron homeostasis dysfunctions have been associated with several metabolic disorders including obesity, steatosis and diabetes. Here the authors demonstrate that the hepcidin repressor matriptase-2 regulates adiposity and its deficiency protects mice against obesity and promotes lipolysis.

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Autores principales:	Alicia R. Folgueras, Sandra Freitas-Rodríguez, Andrew J. Ramsay, Cecilia Garabaya, Francisco Rodríguez, Gloria Velasco, Carlos López-Otín
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d9380d8e26744d9bacd18d51dfcfc31
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spelling	oai:doaj.org-article:7d9380d8e26744d9bacd18d51dfcfc312021-12-02T16:49:18ZMatriptase-2 deficiency protects from obesity by modulating iron homeostasis10.1038/s41467-018-03853-12041-1723https://doaj.org/article/7d9380d8e26744d9bacd18d51dfcfc312018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03853-1https://doaj.org/toc/2041-1723Iron homeostasis dysfunctions have been associated with several metabolic disorders including obesity, steatosis and diabetes. Here the authors demonstrate that the hepcidin repressor matriptase-2 regulates adiposity and its deficiency protects mice against obesity and promotes lipolysis.Alicia R. FolguerasSandra Freitas-RodríguezAndrew J. RamsayCecilia GarabayaFrancisco RodríguezGloria VelascoCarlos López-OtínNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alicia R. Folgueras Sandra Freitas-Rodríguez Andrew J. Ramsay Cecilia Garabaya Francisco Rodríguez Gloria Velasco Carlos López-Otín Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
description	Iron homeostasis dysfunctions have been associated with several metabolic disorders including obesity, steatosis and diabetes. Here the authors demonstrate that the hepcidin repressor matriptase-2 regulates adiposity and its deficiency protects mice against obesity and promotes lipolysis.
format	article
author	Alicia R. Folgueras Sandra Freitas-Rodríguez Andrew J. Ramsay Cecilia Garabaya Francisco Rodríguez Gloria Velasco Carlos López-Otín
author_facet	Alicia R. Folgueras Sandra Freitas-Rodríguez Andrew J. Ramsay Cecilia Garabaya Francisco Rodríguez Gloria Velasco Carlos López-Otín
author_sort	Alicia R. Folgueras
title	Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
title_short	Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
title_full	Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
title_fullStr	Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
title_full_unstemmed	Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
title_sort	matriptase-2 deficiency protects from obesity by modulating iron homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7d9380d8e26744d9bacd18d51dfcfc31
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Matriptase-2 deficiency protects from obesity by modulating iron homeostasis

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