Matriptase-2 deficiency protects from obesity by modulating iron homeostasis

Iron homeostasis dysfunctions have been associated with several metabolic disorders including obesity, steatosis and diabetes. Here the authors demonstrate that the hepcidin repressor matriptase-2 regulates adiposity and its deficiency protects mice against obesity and promotes lipolysis.

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Auteurs principaux: Alicia R. Folgueras, Sandra Freitas-Rodríguez, Andrew J. Ramsay, Cecilia Garabaya, Francisco Rodríguez, Gloria Velasco, Carlos López-Otín
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/7d9380d8e26744d9bacd18d51dfcfc31
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