Extra-coding RNAs regulate neuronal DNA methylation dynamics

DNA methylation in the brain is a dynamic process, but gene-specific regulation of this process is poorly understood. Here, Day and colleagues show that extra-coding RNAs interact with DNA methyltransferases and regulate neuronal DNA methylation to control gene expression in locus-specific manner in...

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Autores principales: Katherine E. Savell, Nancy V. N. Gallus, Rhiana C. Simon, Jordan A. Brown, Jasmin S. Revanna, Mary Katherine Osborn, Esther Y. Song, John J. O’Malley, Christian T. Stackhouse, Allison Norvil, Humaira Gowher, J. David Sweatt, Jeremy J. Day
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/7d938d2a579f49edb66b0941663590e6
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Sumario:DNA methylation in the brain is a dynamic process, but gene-specific regulation of this process is poorly understood. Here, Day and colleagues show that extra-coding RNAs interact with DNA methyltransferases and regulate neuronal DNA methylation to control gene expression in locus-specific manner in neurons.