Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but a...

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Autores principales:	Nasreddine El Omari, Saad Bakrim, Mohamed Bakha, José M. Lorenzo, Maksim Rebezov, Mohammad Ali Shariati, Sara Aboulaghras, Abdelaali Balahbib, Mars Khayrullin, Abdelhakim Bouyahya
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer natural compounds epigenetic epidrugs DNMT Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7d94f0cd6ab34172a3dd1f0f3937dfda
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spelling	oai:doaj.org-article:7d94f0cd6ab34172a3dd1f0f3937dfda2021-11-25T18:33:23ZNatural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates10.3390/nu131137142072-6643https://doaj.org/article/7d94f0cd6ab34172a3dd1f0f3937dfda2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3714https://doaj.org/toc/2072-6643Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates.Nasreddine El OmariSaad BakrimMohamed BakhaJosé M. LorenzoMaksim RebezovMohammad Ali ShariatiSara AboulaghrasAbdelaali BalahbibMars KhayrullinAbdelhakim BouyahyaMDPI AGarticlecancernatural compoundsepigeneticepidrugsDNMTNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3714, p 3714 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer natural compounds epigenetic epidrugs DNMT Nutrition. Foods and food supply TX341-641
spellingShingle	cancer natural compounds epigenetic epidrugs DNMT Nutrition. Foods and food supply TX341-641 Nasreddine El Omari Saad Bakrim Mohamed Bakha José M. Lorenzo Maksim Rebezov Mohammad Ali Shariati Sara Aboulaghras Abdelaali Balahbib Mars Khayrullin Abdelhakim Bouyahya Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
description	Cancer is one of the most complex and systemic diseases affecting the health of mankind, causing major deaths with a significant increase. This pathology is caused by several risk factors, of which genetic disturbances constitute the major elements, which not only initiate tumor transformation but also epigenetic disturbances which are linked to it and which can induce transcriptional instability. Indeed, the involvement of epigenetic disturbances in cancer has been the subject of correlations today, in addition to the use of drugs that operate specifically on different epigenetic pathways. Natural molecules, especially those isolated from medicinal plants, have shown anticancer effects linked to mechanisms of action. The objective of this review is to explore the anticancer effects of alkaloids, terpenoids, quinones, and isothiocyanates.
format	article
author	Nasreddine El Omari Saad Bakrim Mohamed Bakha José M. Lorenzo Maksim Rebezov Mohammad Ali Shariati Sara Aboulaghras Abdelaali Balahbib Mars Khayrullin Abdelhakim Bouyahya
author_facet	Nasreddine El Omari Saad Bakrim Mohamed Bakha José M. Lorenzo Maksim Rebezov Mohammad Ali Shariati Sara Aboulaghras Abdelaali Balahbib Mars Khayrullin Abdelhakim Bouyahya
author_sort	Nasreddine El Omari
title	Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
title_short	Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
title_full	Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
title_fullStr	Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
title_full_unstemmed	Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
title_sort	natural bioactive compounds targeting epigenetic pathways in cancer: a review on alkaloids, terpenoids, quinones, and isothiocyanates
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7d94f0cd6ab34172a3dd1f0f3937dfda
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Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates

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