The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription

BmrR is a member of the bacterial MerR transcription factor family that regulates the expression of the bacterial efflux pump Bmr. Here, the authors present the cryo-EM structure of a B. subtilis transcription activation complex (TAC) containing the RNA Polymerase (RNAP) core enzyme, σA, promoter DN...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chengli Fang, Linyu Li, Yihan Zhao, Xiaoxian Wu, Steven J. Philips, Linlin You, Mingkang Zhong, Xiaojin Shi, Thomas V. O’Halloran, Qunyi Li, Yu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d9919e66d8647f8ae01f45fa7ead1ad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7d9919e66d8647f8ae01f45fa7ead1ad
record_format	dspace
spelling	oai:doaj.org-article:7d9919e66d8647f8ae01f45fa7ead1ad2021-12-02T14:16:55ZThe bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription10.1038/s41467-020-20134-y2041-1723https://doaj.org/article/7d9919e66d8647f8ae01f45fa7ead1ad2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20134-yhttps://doaj.org/toc/2041-1723BmrR is a member of the bacterial MerR transcription factor family that regulates the expression of the bacterial efflux pump Bmr. Here, the authors present the cryo-EM structure of a B. subtilis transcription activation complex (TAC) containing the RNA Polymerase (RNAP) core enzyme, σA, promoter DNA and ligand-bound BmrR, which reveals that in contrast to most other transcription factors BmrR does not directly interact with RNAP and instead activates transcription by modulating the shape of the core promoter.Chengli FangLinyu LiYihan ZhaoXiaoxian WuSteven J. PhilipsLinlin YouMingkang ZhongXiaojin ShiThomas V. O’HalloranQunyi LiYu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chengli Fang Linyu Li Yihan Zhao Xiaoxian Wu Steven J. Philips Linlin You Mingkang Zhong Xiaojin Shi Thomas V. O’Halloran Qunyi Li Yu Zhang The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription
description	BmrR is a member of the bacterial MerR transcription factor family that regulates the expression of the bacterial efflux pump Bmr. Here, the authors present the cryo-EM structure of a B. subtilis transcription activation complex (TAC) containing the RNA Polymerase (RNAP) core enzyme, σA, promoter DNA and ligand-bound BmrR, which reveals that in contrast to most other transcription factors BmrR does not directly interact with RNAP and instead activates transcription by modulating the shape of the core promoter.
format	article
author	Chengli Fang Linyu Li Yihan Zhao Xiaoxian Wu Steven J. Philips Linlin You Mingkang Zhong Xiaojin Shi Thomas V. O’Halloran Qunyi Li Yu Zhang
author_facet	Chengli Fang Linyu Li Yihan Zhao Xiaoxian Wu Steven J. Philips Linlin You Mingkang Zhong Xiaojin Shi Thomas V. O’Halloran Qunyi Li Yu Zhang
author_sort	Chengli Fang
title	The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription
title_short	The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription
title_full	The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription
title_fullStr	The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription
title_full_unstemmed	The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription
title_sort	bacterial multidrug resistance regulator bmrr distorts promoter dna to activate transcription
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7d9919e66d8647f8ae01f45fa7ead1ad
work_keys_str_mv	AT chenglifang thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT linyuli thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT yihanzhao thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT xiaoxianwu thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT stevenjphilips thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT linlinyou thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT mingkangzhong thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT xiaojinshi thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT thomasvohalloran thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT qunyili thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT yuzhang thebacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT chenglifang bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT linyuli bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT yihanzhao bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT xiaoxianwu bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT stevenjphilips bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT linlinyou bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT mingkangzhong bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT xiaojinshi bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT thomasvohalloran bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT qunyili bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription AT yuzhang bacterialmultidrugresistanceregulatorbmrrdistortspromoterdnatoactivatetranscription
_version_	1718391676417867776

The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription

Ejemplares similares