The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure

Abstract On many mink farms, antibiotics are used extensively during the lactation period to reduce the prevalence and severity of pre-weaning diarrhoea (PWD) in mink kits (also referred to as greasy kit syndrome). Concerns have been raised, that routine treatment of PWD with antibiotics could affec...

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Autores principales:	Martin Iain Bahl, Anabelle Legarth Honoré, Sanne Tygesen Skønager, Oliver Legarth Honoré, Tove Clausen, Lars Andresen, Anne Sofie Hammer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7d9c6f23807f4c4d95acc3a71be1e024
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spelling	oai:doaj.org-article:7d9c6f23807f4c4d95acc3a71be1e0242021-12-02T12:33:44ZThe microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure10.1038/s41598-020-77417-z2045-2322https://doaj.org/article/7d9c6f23807f4c4d95acc3a71be1e0242020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77417-zhttps://doaj.org/toc/2045-2322Abstract On many mink farms, antibiotics are used extensively during the lactation period to reduce the prevalence and severity of pre-weaning diarrhoea (PWD) in mink kits (also referred to as greasy kit syndrome). Concerns have been raised, that routine treatment of PWD with antibiotics could affect the natural successional development of the gut microbiota, which may have long lasting consequences. Here we investigated the effects of early life antibiotic treatment administered for 1 week (postnatal days 13–20). Two routes of antibiotic administration were compared to a non-treated control group (CTR, n = 24). Routes of administration included indirect treatment, through the milk from dams receiving antibiotics by intramuscular administration (ABX_D, n = 24) and direct treatment by intramuscular administration to the kits (ABX_K, n = 24). A tendency for slightly increased weight at termination (Day 205) was observed in the ABX_K group. The gut microbiota composition was profiled by 16S rRNA gene sequencing at eight time points between Day 7 and Day 205. A clear successional development of the gut microbiota composition was observed and both treatment regimens caused detectable changes in the gut microbiota until at least eight days after treatment ceased. At termination, a significant positive correlation was identified between microbial diversity and animal weight.Martin Iain BahlAnabelle Legarth HonoréSanne Tygesen SkønagerOliver Legarth HonoréTove ClausenLars AndresenAnne Sofie HammerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Iain Bahl Anabelle Legarth Honoré Sanne Tygesen Skønager Oliver Legarth Honoré Tove Clausen Lars Andresen Anne Sofie Hammer The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
description	Abstract On many mink farms, antibiotics are used extensively during the lactation period to reduce the prevalence and severity of pre-weaning diarrhoea (PWD) in mink kits (also referred to as greasy kit syndrome). Concerns have been raised, that routine treatment of PWD with antibiotics could affect the natural successional development of the gut microbiota, which may have long lasting consequences. Here we investigated the effects of early life antibiotic treatment administered for 1 week (postnatal days 13–20). Two routes of antibiotic administration were compared to a non-treated control group (CTR, n = 24). Routes of administration included indirect treatment, through the milk from dams receiving antibiotics by intramuscular administration (ABX_D, n = 24) and direct treatment by intramuscular administration to the kits (ABX_K, n = 24). A tendency for slightly increased weight at termination (Day 205) was observed in the ABX_K group. The gut microbiota composition was profiled by 16S rRNA gene sequencing at eight time points between Day 7 and Day 205. A clear successional development of the gut microbiota composition was observed and both treatment regimens caused detectable changes in the gut microbiota until at least eight days after treatment ceased. At termination, a significant positive correlation was identified between microbial diversity and animal weight.
format	article
author	Martin Iain Bahl Anabelle Legarth Honoré Sanne Tygesen Skønager Oliver Legarth Honoré Tove Clausen Lars Andresen Anne Sofie Hammer
author_facet	Martin Iain Bahl Anabelle Legarth Honoré Sanne Tygesen Skønager Oliver Legarth Honoré Tove Clausen Lars Andresen Anne Sofie Hammer
author_sort	Martin Iain Bahl
title	The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
title_short	The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
title_full	The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
title_fullStr	The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
title_full_unstemmed	The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure
title_sort	microbiota of farmed mink (neovison vison) follows a successional development and is affected by early life antibiotic exposure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7d9c6f23807f4c4d95acc3a71be1e024
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The microbiota of farmed mink (Neovison vison) follows a successional development and is affected by early life antibiotic exposure

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