Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

How and where VEGF-C is processed in lymphangiogenesis is unclear. Here, the authors show that development of the zebrafish lymphatic system is locally restricted by Vegfc maturation causing lymphatic sprouting in certain regions, which is regulated by the metalloproteases ADAMTS3 and ADAMTS14.

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Autores principales:	Guangxia Wang, Lars Muhl, Yvonne Padberg, Laura Dupont, Josi Peterson-Maduro, Martin Stehling, Ferdinand le Noble, Alain Colige, Christer Betsholtz, Stefan Schulte-Merker, Andreas van Impel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7d9c7602b7f54a6bbd0b0e6fd9867d83
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spelling	oai:doaj.org-article:7d9c7602b7f54a6bbd0b0e6fd9867d832021-12-02T17:51:19ZSpecific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis10.1038/s41467-020-16552-72041-1723https://doaj.org/article/7d9c7602b7f54a6bbd0b0e6fd9867d832020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16552-7https://doaj.org/toc/2041-1723How and where VEGF-C is processed in lymphangiogenesis is unclear. Here, the authors show that development of the zebrafish lymphatic system is locally restricted by Vegfc maturation causing lymphatic sprouting in certain regions, which is regulated by the metalloproteases ADAMTS3 and ADAMTS14.Guangxia WangLars MuhlYvonne PadbergLaura DupontJosi Peterson-MaduroMartin StehlingFerdinand le NobleAlain ColigeChrister BetsholtzStefan Schulte-MerkerAndreas van ImpelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guangxia Wang Lars Muhl Yvonne Padberg Laura Dupont Josi Peterson-Maduro Martin Stehling Ferdinand le Noble Alain Colige Christer Betsholtz Stefan Schulte-Merker Andreas van Impel Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
description	How and where VEGF-C is processed in lymphangiogenesis is unclear. Here, the authors show that development of the zebrafish lymphatic system is locally restricted by Vegfc maturation causing lymphatic sprouting in certain regions, which is regulated by the metalloproteases ADAMTS3 and ADAMTS14.
format	article
author	Guangxia Wang Lars Muhl Yvonne Padberg Laura Dupont Josi Peterson-Maduro Martin Stehling Ferdinand le Noble Alain Colige Christer Betsholtz Stefan Schulte-Merker Andreas van Impel
author_facet	Guangxia Wang Lars Muhl Yvonne Padberg Laura Dupont Josi Peterson-Maduro Martin Stehling Ferdinand le Noble Alain Colige Christer Betsholtz Stefan Schulte-Merker Andreas van Impel
author_sort	Guangxia Wang
title	Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
title_short	Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
title_full	Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
title_fullStr	Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
title_full_unstemmed	Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis
title_sort	specific fibroblast subpopulations and neuronal structures provide local sources of vegfc-processing components during zebrafish lymphangiogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7d9c7602b7f54a6bbd0b0e6fd9867d83
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Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

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